Modification with transmission blocking agents on the induction of long-term potentiation in the rat cerebral intracortical evoked potentials

In the adult Wistar rat maintained under the modified neuroleptanalgesia with droperidol and pentazocine, the intracortical microstimulation (ICMS) was applied to the lamina V of the motorsensory cortex, and thereby evoked field potentials were simultaneously recorded at two spots by 0.7-2.0 mm apar...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1996, Vol.71 (suppl.1), p.100-100
Main Authors: Sanae Tomizawa, Keiko Arai, Osamu Hidoh, Yoji Shiobara, Tomokazu Oshima
Format: Article
Language:Japanese
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Summary:In the adult Wistar rat maintained under the modified neuroleptanalgesia with droperidol and pentazocine, the intracortical microstimulation (ICMS) was applied to the lamina V of the motorsensory cortex, and thereby evoked field potentials were simultaneously recorded at two spots by 0.7-2.0 mm apart in the nearby lamina III. While one spot served as a control, the other was locally exposed to a solution containing 2-amino-5-phosphonovalerate or atropine injected through a microsyringe before application of tetanic ICMS (several sets of 10 pulses at 200 Hz with 10-sec intervals) that could induce long-term potentiation (LTP). Both the agents showed modificatory actions on LTP, which were most frequently depressant. The results suggest that the induction of LTP in the rat in vivo motorsensory cortex involves N-methyl-D-aspartate receptor-mediated glutamatergic as well as muscarinic synaptic mechanisms.
ISSN:0021-5198