Studies on chronic obstructive pulmonary disease

The main risk factor of chronic obstructive pulmonary disease (COPD) is chronic smoking. To establish COPD model in guinea pigs, we investigated the effect of cigarette smoke exposure on respiratory function. Guinea pigs were exposed to smoke of commercial cigarettes using a standard smoking machine...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 2000, Vol.82 (suppl.2), p.247-247
Main Authors: Jun-ichi Fuchikami, Kousuke Morizumi, Maki Matsuda, Aya Akahoshi, Satoko Naka, Matsuko Moriyasu, Hirofumi Kai, Takeshi Miyata
Format: Article
Language:Japanese
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Summary:The main risk factor of chronic obstructive pulmonary disease (COPD) is chronic smoking. To establish COPD model in guinea pigs, we investigated the effect of cigarette smoke exposure on respiratory function. Guinea pigs were exposed to smoke of commercial cigarettes using a standard smoking machine, given during 0.5, 1 or 2hr period each day, 5 days per one week, for 2 or 4 weeks. Age-matched control group was sham-smoked. Respiratory function was measured by a double flow plethysmograph in conscious animals. After that, cell number in broncho-alveolar lavage fluid (BALF) was counted. In the cigarette smoke exposed guinea-pigs, specific airway resistance was slightly increased, and tidal volume, peak expiratory flow, minutes volume and respiratory rate were decreased. Also cigarette smoke exposure produced increase of inflammatory cells in BALF. These responses are similar to those in COPD subjects, and suggest that this model may be useful to evaluate the action of drugs and to study the mechanism of the COPD.
ISSN:0021-5198