Effects of ifenprodil on discriminative stimulus effects of cocaine in rhesus monkeys

Ifenprodil is a non-competitive NMDA receptor antagonist which prefers NR2B-containing NMDA receptors to NR2A-containing NMDA receptors. It has been reported that ifenprodil suppresses the morphine-induced place preference in mice. In this study, effects of ifenprodil on discriminative stimulus effe...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2004, Vol.94 (suppl.2), p.175-175
Main Authors: Atsushi Fujiwara, Yoshio Wakasa, Mikio Sasaki, Mitsuru Hoshino, Masahiko Iino, Takahiro Ootsuka, Naoyuki Hironaka, Tomoji Yanagita
Format: Article
Language:Japanese
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Summary:Ifenprodil is a non-competitive NMDA receptor antagonist which prefers NR2B-containing NMDA receptors to NR2A-containing NMDA receptors. It has been reported that ifenprodil suppresses the morphine-induced place preference in mice. In this study, effects of ifenprodil on discriminative stimulus effects of cocaine were observed in rhesus monkeys. Five monkeys were trained to discriminate i. m injections of 0.25 or 0.5 mg/kg of cocaine from saline using a standard two-lever drug-discrimination paradigm under a fixed-ratio schedule of food reinforcement. Single administration of cocaine (0.06-0.5 mg/kg) produced a dose-dependent increase in cocaine-appropriate responding, and training doses produced 100% cocaine-lever responding in each monkey. Pretreatment with ifenprodil (1 mg/kg, i. v. ) produced dose-dependent rightward shifts in the cocaine discrimination dose-response curve in three of five monkeys. This result suggests that NR2B-containing NMDA receptors may be involved in the mechanism underlying discriminative stimulus effects of cocaine.
ISSN:1347-8613