Increase in hepatic mRNA expression of fibrinogen in spontaneously hypertensive and hyperlipidemic rats (SHHRs)

As a risk factor for cardiovascular and cerebrovascular disease, hypertension and hyperlipidemia are conceived to provoke vascular damage leading to a hypercoagulable state. The present study was to investigate the coagulation and fibrinolysis activity and hepatic mRNA expression of coagulative fact...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2004, Vol.94 (suppl.3), p.271-271
Main Authors: Hidetoshi Amagasa, Masako Okazaki, Shinichi Iwai, Yasutaka Takinishi, Akio Yokochi, Masanobu Watanabe, Toshio Kumai, Shinichi Kobayashi, Katsuji Oguchi
Format: Article
Language:Japanese
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Summary:As a risk factor for cardiovascular and cerebrovascular disease, hypertension and hyperlipidemia are conceived to provoke vascular damage leading to a hypercoagulable state. The present study was to investigate the coagulation and fibrinolysis activity and hepatic mRNA expression of coagulative factors using male and female SHHRs (>150 mmHg of systolic blood pressure, >150 mg/dl of plasma cholesterol). Plasma levels of fibrinogen and thrombin-antithrombin III complex in male and female SI-IHRs at 9 months of age increased significantly compared with those of age-matched Sprague-Dawley rats. In SHHRs, hepatic mRNA expression of α and β-chains of fibrinogen was significantly enhanced, but not y-chain of fibrinogen and prothrombin determined by RT-PCR. Therefore, the hyperfibrinogenemia in SHHRs was demonstrated due to the increase in mRNA expression of α- and β-chains of fibrinogen. Our results suggest that the hypercoagulation with the increase in hepatic mRNA expression of fibrinogen components may contribute to the development of atherosclerosis in SHHRs.
ISSN:1347-8613