Effects of Bemiparin, Dalteparin, and Unfractionated Heparin on Platelet Interaction With Human Subendothelium Under Flow Conditions

「Abstract」We compared the effects of the low-molecular-weight heparin （LMWH）, bemiparin, and dalteparin with unfractionated heparin （UFH） on the platelet subendothelium interaction under flow conditions. All three compounds decreased the percentage of subendothelial matrix covered by platelets, alth...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2008-05, Vol.107 (1), p.103-106
Main Authors: Jose Antonio Gonzalez-Correa, Maria Monsalud Arrebola, Francisco Merida, Maria Dolores Navas, Juan Antonio Lopez-Villodres, Felisa Samanes, Jose Pedro De La Cruz
Format: Article
Language:Japanese
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Summary:「Abstract」We compared the effects of the low-molecular-weight heparin （LMWH）, bemiparin, and dalteparin with unfractionated heparin （UFH） on the platelet subendothelium interaction under flow conditions. All three compounds decreased the percentage of subendothelial matrix covered by platelets, although the effect of LMWH was greater than that of UFH. Subendothelial matrix covered with platelet structures greater than 100 square microns was significantly reduced by all three compounds； the effect of bemiparin tended to be greater than that of the other two heparins. Low-molecular-weight heparins （LMWH） have been shown to be effective in the prevention and treatment of venous thromboembolism （1）, and they are associated with a lower incidence of bleeding than unfractionated heparins. In addition, LMWH has been found to be effective in the secondary prevention of ischemic arterial accidents （acute coronary syndrome, stroke, etc. ）（2）. In these arterial processes, the interaction of platelets with the vascular subendothelium is an important factor in the pathogenesis and course of ischemia.
ISSN:1347-8613