Signal Transduction Pathways Regulating the Radioadaptive Response

Radioadaptive response is the acquirement of cellular resistance to ionizing radiation by prior exposure to low dose. Accumulating evidence for the presence in diverse organisms suggests a fundamental cellular defense mechanism. However, the molecular mechanisms and signalling pathways responsible f...

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Bibliographic Details
Published in:JOURNAL OF RADIATION RESEARCH 1998, Vol.39 (4), p.316-316
Main Author: Tomohisa KATO
Format: Article
Language:Japanese
Online Access:Get full text
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Summary:Radioadaptive response is the acquirement of cellular resistance to ionizing radiation by prior exposure to low dose. Accumulating evidence for the presence in diverse organisms suggests a fundamental cellular defense mechanism. However, the molecular mechanisms and signalling pathways responsible for its regulation are largely unknown. During the course of characterizing a null mutant of phhl^+ /styl^+ /spcl^+ gene of Schizosaccharomyces pombe, we found that disrupting the phhl^+ gene results in abrogation of the radioadaptive response in S. pombe. We moved to the mammalian cell system, in which the radioadaptive response is well studied. p38 MAP kinase, the mammalian homolog of phhl^+ , is activated in response to low dose of X-rays (0.02 Gy). Furthermore. SB203580, a specific inhibitor of p3 MAP kinase, blocked the radioadaptive response revealed by the modulation of chromosome aberration formation in a combined treatment with 0.02 and 3 Gy.
ISSN:0449-3060