269 Significance of beta term in carbon-ion radiotherapy

Biological effectiveness of carbon ions was compared between an experimentaltumor (NFSa fibrosarcoma) and skin of syngeneic C3H mice. 290 MeV/u carbon ions of LET 42 and 77 keV/micrometer, but not 14 or 20 keV/micromete, showed larger RBE (biological effectiveness relative to gamma rays) values in r...

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Published in:JOURNAL OF RADIATION RESEARCH 2003, Vol.44 (4), p.452-452
Main Authors: Koichi ANDO, Akiko UZAWA, Takeshi FUKAWA, Nobuhiko TAKAI, Mizuho AOKI, Sachiko KOIKE, Yoshiya FURUSAWA, Yasuyuki MIYATO, Manami MONOBE, Guangming ZHOU
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Language:Japanese
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Summary:Biological effectiveness of carbon ions was compared between an experimentaltumor (NFSa fibrosarcoma) and skin of syngeneic C3H mice. 290 MeV/u carbon ions of LET 42 and 77 keV/micrometer, but not 14 or 20 keV/micromete, showed larger RBE (biological effectiveness relative to gamma rays) values in retarding tumor growth than causing skin reaction after dailyfractionated irradiation. Single doses failed to show therapeutic gain for any LET of carbon ions. RBE values of the two tissues for 14 and 20 keV/micrometer ranged from 1.2 and 1.7. The alpha term increased with an increase in LET irrespective of tumor or skin, while the beta term of skin, but not of tumor, increased with LET. It is implied that high-LET radiotherapy could achieve large therapeutic gain comparing to photon therapy when a fractionation scheme consisting of a large dose with small number of fractionation is used.
ISSN:0449-3060