Isochromosome 17q ; A Novel Finding in Myeloid Sarcoma

[TO THE EDITOR] Chromosome 17 abnormalities in haematologic malignancies are important because the TP53 tumour suppressor gene is found on 17p 13.1. Chromosome 17 abnormalities were reported in 49 (4.3%) of cases in a study of patients with myelodysplastic syndrome (MDS) and acute myeloid leukaemia...

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Bibliographic Details
Published in:Journal of Clinical and Experimental Hematopathology 2016-12, Vol.56 (2), p.130-134
Main Authors: Sanjay de Mel, Joanne Lee, Constance Chua, Sok Peng Chua, Leena Gole, Limei Poon, Jenny Li, Siok Bian Ng, Te Chih Liu, Wee Joo Chng, Yen Lin Chee
Format: Article
Language:Japanese
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Summary:[TO THE EDITOR] Chromosome 17 abnormalities in haematologic malignancies are important because the TP53 tumour suppressor gene is found on 17p 13.1. Chromosome 17 abnormalities were reported in 49 (4.3%) of cases in a study of patients with myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). In this cohort, 14 patients had monosomy 17 and 35 patients had unbalanced translocations between chromosome 17p and another chromosome. Most of them also had other cytogenetic abnormalities and 10 were therapy related, 69% also had a TP53 mutation. The pseudo Pelger-Huet like anomaly and vacuolated neutrophils were described in 70% of these patients. Chromosome 17 abnormalities have also been associated with therapy related myeloid neoplasms, unbalanced translocations involving chromosome 17, monosomy 17 and isochromosome 17q or 17p deletion having been reported. Isochromosome(17q) occurs when chromosome 17 has two identical arms, i.e. no "p" arm but two "q" arms.
ISSN:1346-4280