Lack of Puberty Despite Elevated Estradiol in a 46,XY Phenotypic Female with Frasier Syndrome

Frasier syndrome is characterized by slowly progressive nephropathy, male pseudohermaphroditism, streak gonad, and high risk of gonadoblastoma development. Here we report a case of a 46, XY phenotypic female with Frasier syndrome, who was under hemodialysis. While her serum estradiol level was gradu...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2006, Vol.53 (3), p.371-376
Main Authors: YOKO MIYOSHI, YOKO SANTO, KANAKO TACHIKAWA, NORIYUKI NAMBA, HARUHIKO HIRAI, SOTARO MUSHIAKE, SHIGEO NAKAJIMA, TOSHIMI MICHIGAMI, KEIICHI OZONO
Format: Article
Language:Japanese
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Summary:Frasier syndrome is characterized by slowly progressive nephropathy, male pseudohermaphroditism, streak gonad, and high risk of gonadoblastoma development. Here we report a case of a 46, XY phenotypic female with Frasier syndrome, who was under hemodialysis. While her serum estradiol level was gradually increasing annually, gonadotropin level was constantly extremely high, and her appearance was still prepubertal. She was heterozygous for a novel guanine > adenine point mutation at position +1 of the splice donor site within intron 9 (IVS 9 + 1G > A) of the Wilms' tumor 1 gene. The possibility of this disease should be taken into consideration whenever we encounter a patient with steroid-resistant nephrotic syndrome and delayed puberty.
ISSN:0918-8959