Aldosterone excess may inhibit insulin secretion : A comparative study on glucose metabolism pre- and post-adrenalectomy in patients with primary aldosteronism

[Abstract.] Conflicting data have been published on the effects of aldosterone excess on glucose metabolism. Specifically, there are limited data on whether adrenalectomy in patients with aldosterone-producing adenomas (APA) can improve glucose metabolism. In this study we evaluated changes in gluco...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2017-03, Vol.64 (3), p.339-346
Main Authors: Yuya Tsurutani, Chiho Sugisawa, Akiko Ishida, Kosuke Inoue, Jun Saito, Masao Omura, Shoichiro Nagasaka, Tetsuo Nishikawa
Format: Article
Language:Japanese
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Summary:[Abstract.] Conflicting data have been published on the effects of aldosterone excess on glucose metabolism. Specifically, there are limited data on whether adrenalectomy in patients with aldosterone-producing adenomas (APA) can improve glucose metabolism. In this study we evaluated changes in glucose metabolism, before and after surgery for APA. The subjects were 61 patients treated with unilateral adrenalectomy, localized by adrenal venous sampling. A 75g-oral glucose tolerance test (OGTT) was performed before and 1 year after adrenalectomy. Patients with diabetes mellitus or a serum cortisol level >3 μg/dL after a 1 mg dexamethasone suppression test, were excluded. Using the 75g-OGTT data, insulin secretion and insulin resistance (or sensitivity) indices were calculated. The results showed that immunoreactive insulin levels during the OGTT increased significantly after adrenalectomy, whereas plasma glucose levels, before and after surgery, were comparable. The insulinogenic index significantly increased after surgery (0.5 [0.4-0.8] to 0.8 [0.4-1.1], p
ISSN:0918-8959