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False-positive TSH receptor antibody results in an infant with activating TSHR mutation

[Dear Editor,] Wada et al. [1] reported the occurrence of false-positive TSH receptor antibody results in neonates and healthy volunteers using lithium-heparin plasma in a third-generation anti-TSHR platform (Elecsys(R) Anti-TSHR, Roche Diagnostics Ltd., Basel, Switzerland). We encountered a case of...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2018, Vol.65 (7), p.793-794
Main Authors: Felix CK Wong, Elaine YL Au, Ricky WK Ip, Ho Chung Yau, Lydia CW Lit
Format: Article
Language:Japanese
Online Access:Get full text
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Summary:[Dear Editor,] Wada et al. [1] reported the occurrence of false-positive TSH receptor antibody results in neonates and healthy volunteers using lithium-heparin plasma in a third-generation anti-TSHR platform (Elecsys(R) Anti-TSHR, Roche Diagnostics Ltd., Basel, Switzerland). We encountered a case of discrepant TSH receptor antibody results in an infant with activating TSH receptor mutation. The Chinese male infant was delivered preterm (33 week 5 days) for suspected fetal distress. He had persistent tachycardia after birth and thyroid function tests on day 10 showed a suppressed TSH (100 pmol/L). The mother was clinically and biochemically euthyroid with no personal history of thyroid disease. Family history of thyroid diseases was negative.
ISSN:0918-8959