Mechanism of Action of Dipropofol and Synergistic Action with Other Antibacterial Agents in Vitro

The mode of action of dipropofol and its antibacterial activity in combination with other antibiotics against Gram-positive and -negative bacteria were investigated. Dipropofol showed a bactericidal effect against Staphylococcus aureus 209P, and inhibited the incorporations of 3H-glutamate and 3H-le...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28 (9), p.1773-1775
Main Authors: Masahiro OGATAa, c, Takao KUNIKANEb, Masako SEKIb, Kentaro OKAb, Shiro URANOc, Sachiko SEKIa, Yasuhide SEKIa, Toyoshige ENDOb
Format: Article
Language:Japanese
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Summary:The mode of action of dipropofol and its antibacterial activity in combination with other antibiotics against Gram-positive and -negative bacteria were investigated. Dipropofol showed a bactericidal effect against Staphylococcus aureus 209P, and inhibited the incorporations of 3H-glutamate and 3H-leucine into S. aureus 209P and Bacillus subtilis PCI219 cells. These results indicated that the mechanism of action of dipropofol was mediated by the inhibition of protein synthesis or amino acid incorporation. A synergistic effect was performed by checkerboard titration with Muller-Hinton agar plates containing dipropofol (0.39 μg/ml, 1/4×MIC) and various concentrations of nine other antibiotics in vitro. The synergism against vancomycin resistant Enterococcus faecium was confirmed in the combination of dipropofol with rifampicin. The MIC of rifampicin was decreased from 0.39 μg/ml to
ISSN:0918-6158