Cladribine Enhances Apoptotic Cell Death in Lung Carcinoma Cells Over-Expressing DNase γ

Worldwide, lung cancer is the most common form of cancer and often has a poor prognosis. Establishment of effective therapies for lung cancer is a major concern in clinical cancer research. We compared the cytotoxic effects of chemotherapeutic agents including cisplatin, 5-fluorouracil, vinorelbine...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2011-07, Vol.34 (7), p.1001-1004
Main Authors: Akemi HAYAKAWAa, b, Haruhiko SUZUKIc, Yuzuru KAMEIb, Sei-ichi TANUMAd, Junji MAGAEe
Format: Article
Language:Japanese
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Summary:Worldwide, lung cancer is the most common form of cancer and often has a poor prognosis. Establishment of effective therapies for lung cancer is a major concern in clinical cancer research. We compared the cytotoxic effects of chemotherapeutic agents including cisplatin, 5-fluorouracil, vinorelbine and cladribine, on a human lung cancer cell line, A549, and its derivative transfected with the DNase γ gene. We observed selective cytotoxicity of cladribine on the DNase γ-expressing sub-cell line of A549. Cladribine induces selective apoptosis in DNase 7-expressing A549 cells, which depends on activation of caspases. These results suggest that a combination therapy that includes cladribine along with the introduction of DNase γ has potential as a new therapeutic strategy for lung cancer.
ISSN:0918-6158