Physiological Functions and Underlying Mechanisms of Fibroblast Growth Factor (FGF) Family Members : Recent Findings and Implications for Their Pharmacological Application

Despite their name, fibroblast growth factors (FGFs) are multifunctional regulators affecting a wide variety of physiological events. This review summarizes our recent studies on FGFs from mechanistic, physiological and application-oriented viewpoints. These include studies on the importance of βKlo...

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Bibliographic Details
Published in:Biological and Pharmaceutical Bulletin 2014-07, Vol.37 (7), p.1081-1089
Main Author: Toru Imamura
Format: Article
Language:Japanese
Online Access:Get full text
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Summary:Despite their name, fibroblast growth factors (FGFs) are multifunctional regulators affecting a wide variety of physiological events. This review summarizes our recent studies on FGFs from mechanistic, physiological and application-oriented viewpoints. These include studies on the importance of βKlotho and glycosaminoglycans for the signaling of hormonal FGFs (FGF21 and FGF19); the physiological role of a paracrine FGF (FGF18) in hair cycle regulation; and the development of a stable, chimeric FGF protein composed of FGF1 and FGF2 domains suitable for radioprotection.
ISSN:0918-6158