Relationship between Exhaled Nitric Oxide Measured by Two Offline Methods and Bronchial Hyperresponsiveness in Japanese Adults with Asthma

Background: Exhaled nitric oxide (eNO) is a useful marker of eosinophilic airway inflammation in asthmatics. There have been no studies to show the relationship between eNO measured by offline methods and the degree of bronchial hyperresponsiveness in asthmatic patients treated with inhaled corticos...

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Published in:Allergology International 2008, Vol.57 (3), p.223-229
Main Authors: Takahiro Tsuburai, Naomi Tsurikisawa, Sonoko Morita, Hideki Hasunuma, Hiroshi Kanegae, Yasushi Ishimaru, Yuma Fukutomi, Hidenori Tanimoto, Emiko Ono, Chiyako Oshikata, Kiyoshi Sekiya, Mamoru Otomo, Yuji Maeda, Masami Taniguchi, Kunihiko Ikehara, Kazuo Akiyama
Format: Article
Language:Japanese
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Summary:Background: Exhaled nitric oxide (eNO) is a useful marker of eosinophilic airway inflammation in asthmatics. There have been no studies to show the relationship between eNO measured by offline methods and the degree of bronchial hyperresponsiveness in asthmatic patients treated with inhaled corticosteroids. Methods: The study population comprised asthmatics at our outpatient clinic. We measured eNO levels by two methods (“eNOs”was measured with a Sievers kit; and “eNOc”was measured with a kit from the Center for Environmental Information Science, Japan). We also used spirometry to test bronchial hyperresponsiveness to acetylcholine (PC20Ach). Results: We recruited 192 stable asthmatics. There was a significant relationship between eNOs and eNOc (r＝0.919, p
ISSN:1323-8930