Step by Step Improvement of Peripheral Polyneuropathy Associated with Churg-Strauss Syndrome by Six Courses of High-Dose Intravenous Immunoglobulin Therapy

Churg-Strauss syndrome (CSS) is a systemic vasculitis, developing with peripheral blood eosinophilia under a background of an upper respiratory disease. It involves multiorgan systems.1 Most of the Japanese CSS patients develop the peripheral nervous system, that frequently leaves residual damage as...

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Bibliographic Details
Published in:Allergology International 2012-09, Vol.61 (3), p.503-505
Main Authors: Hiromitsu Asashima, Shigeko Inokuma, Hiroki Yamada
Format: Article
Language:Japanese
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Summary:Churg-Strauss syndrome (CSS) is a systemic vasculitis, developing with peripheral blood eosinophilia under a background of an upper respiratory disease. It involves multiorgan systems.1 Most of the Japanese CSS patients develop the peripheral nervous system, that frequently leaves residual damage as a major clinical problem, although corticosteroids and cyclophosphamide are efficacious.2 Since a good response to high-dose intravenous immunoglobulin (IVIg) therapy was first reported in CSS in 1991, several studies have confirmed its efficacy, particularly for peripheral neuropathy.3-5 However, the optimal number of courses for the satisfactory treatment has not yet been known. We treated a case of CSS with severe polyneuropathy successfully by six sequential courses of IVIg. A 61-year-old female, having suffered from bronchial asthma for 4 years, felt progressive numbness of her extremities, developed drop hands and feet, and became not able to walk at all 3 months before visiting our hospital.
ISSN:1323-8930