Development of a prediction model for a severe reaction in cow's milk challenges

• Published in: Allergology International 2017-07, Vol.66 (3), p.493-494
• Main Authors: Shiro Sugiuraa, b, Kemal Sasakia, Teruaki Matsuia, Tomoko Nakagawaa, Naoyuki Kandoa, Komei Itoa
• Format: Article
• Language: Japanese
• ISSN: 1323-8930

Dear Editor, In addition to their conventional purposes, which is for the definitive diagnosis of a food allergy or for the discernment of tolerance to the allergen, oral food challenges (OFCs) are performed to determine the threshold dose of food allergens for risk-assessment or minimal avoidance. More severe reactions tend to be provoked in these OFC settings. We have already reported a model for predicting severe allergic reactions provoked in boiled egg challenges. In the present study, we developed a model for predicting a severe reaction to a milk OFC. This new model was developed via a similar method to that used for the egg challenge. An open OFC of milk was performed in accordance with the Japanese Guideline for Food Allergy 2014 throughout the study period. Raw cow's milk was administered in a gradient dose (typically 4 to 5 doses from 0.2-0.5-1-2-5-10-20 ml) every 30-40 min. The challenge was stopped if the patient exhibited an objective allergic reaction corresponding to >=5 points of the total score (TS) of Anaphylaxis Scoring Aichi (ASCA).