Anaphylaxis associated with eosinophilic sialodochitis via periostin upregulation and mast cell activation

• Published in: Allergology International 2023-04, Vol.72 (2), p.354-356
• Main Authors: Ayano Maruyamaa, Risa Tamagawa-Mineokaa, Shigeharu Uekib, Koji Masudaa, Makoto Yasudac, Eiichi Konishid, Satoshi Nunomurae, Kenji Izuharae, Misaki Arimab, Norito Katoha
• Format: Article
• Language: Japanese
• ISSN: 1323-8930

Dear Editor, Eosinophilic sialodochitis (ES), first reported by Kussmaul in 1879, is characterized by swelling of the salivary glands and discharge of mucus plugs from the saliva tube. Approximately 60 cases have been reported to date. Before the onset of ES, many patients have a long-term chronic eosinophilic disease, such as asthma, allergic rhinitis, or atopic dermatitis. Recently, it was reported that eosinophil extracellular trap cell death (EETosis) might play an important role in the formation of ES mucus plugs. Herein, we report a case of ES-associated episodic anaphylaxis through IgE-independent mechanisms. A 64-year-old Japanese woman developed chronic allergic rhinitis. She had noticed a swelling in her submandibular region over the past 5 years, gradually increasing in incidence. She began to have generalized urticaria and swelling in the submandibular region while eating regardless of meal contents. She was under oral antihistamines for a year, as prescribed by her previous doctor.