Spontaneous Cardiac Hypertrophy in a Crl:CD(SD) Rat

[Abstract]: Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were observed. Necropsy revealed an increase in heart weig...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2009, Vol.22 (1), p.83-87
Main Authors: Tomo Suzuki, Shoichi Kado, Minoru Ando, Yuriko Nagata, Shin Iwata, Toshihide Kobayashi, Kazumi Uchida
Format: Article
Language:Japanese
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Summary:[Abstract]: Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were observed. Necropsy revealed an increase in heart weight. Gross examination indicated cardiac enlargement with thickening of the right and left ventricular walls. Histopathological examination revealed hypertrophy of the cardiomyocytes in the right and left ventricular walls and the interventricular septum. Electron microscopic examination indicated bizarre nuclei and accumulation of an increased number of various sizes of mitochondria in the perinuclear region of the hypertrophied myocytes. Hypertrophied myocytes connected by intensely folded intercalated disks were also observed. Based on these findings, the animal was diagnosed with cardiac hypertrophy. This is the first case report of cardiac hypertrophy in this strain. (J Toxicol Pathol 2009;22:83-87) Cardiac hypertrophy is cellular adaptation of the heart in response to pressure or volume overload that results from hypertension and cardiovascular malformations such as ventricular septal defect (VSD) and valvular heart disease.
ISSN:0914-9198