7. EpiDerm Skin Corrosion Test:Evidence of Long Term Reproducibility and Reliability for a Regulatory Accepted Method

The potential of chemicals to cause skin effects such as corrosion is a concern of industrial toxicologists in their assessments of possible worker and consumer safety issues. Moreover, the U.S. Department of Transportation(DOT), the new regulation on the Registration, Evaluation and Authorization o...

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Bibliographic Details
Published in:Alternatives to Animal Testing and Experimentation 2007, Vol.12 (3), p.227-227
Main Author: Mitchell Klausner
Format: Article
Language:Japanese
Online Access:Get full text
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Summary:The potential of chemicals to cause skin effects such as corrosion is a concern of industrial toxicologists in their assessments of possible worker and consumer safety issues. Moreover, the U.S. Department of Transportation(DOT), the new regulation on the Registration, Evaluation and Authorization of Chemicals(REACH), and other international and national regulatory agencies require that substances should be labeled as to skin corrosivity potential for tissue destruction. In the past, skin corrosion assessments were based on tests involving topical application of test substances to the skin of rabbits. However, based on an ECVAM Validation studies performed during 1999-2000, the OECD approved use of the EpDerm reconstructed human skin model as regulatory accepted method(OECD TG 431)replacing the in vivo test.
ISSN:1344-0411