III-3 Localization of CD31, CD34, and CD105 as a Measure of Microvessel Density in Cervix Neoplasms

「Background」：It is well known that angiogenesis play important role in growth, progression, and metastasis of tumors. In previous reports using various endothelial markers, there is discrepancy due to the variation of immunoreactivities of each antibody. Furthermore, most of these reports used invas...

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Published in:Journal of Hard Tissue Biology 2004, Vol.13 (2), p.99-99
Main Authors: Cheng-Hsiung Roan, Kojun Setsu, Masahisa Inoue, Hitoshi Nagatsuka, Noriyuki Nagai
Format: Article
Language:Japanese
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Summary:「Background」：It is well known that angiogenesis play important role in growth, progression, and metastasis of tumors. In previous reports using various endothelial markers, there is discrepancy due to the variation of immunoreactivities of each antibody. Furthermore, most of these reports used invasive carcinomas. 「Methods」：To investigate angiogenic property of human cervix neoplasm, we used three antibodies (CD31, CD34 and CD105) as a wide panel of blood vessel markers for immunohistochemistry. Cervical intraepithelial neoplasms (CIN) I, II, III, and invasive squamous cell carcinomas (SCC) were used in this study. 「Results」：Many blood vessels stained with these markers were present in connective tissues not only on invasive SCC but also on CIN. Microvessel density tended to increase with disease stage. These results suggest that cervical neoplasm may affect the angiogenesis in connective tissues even at the stage of CIN and the degree of angiogenesis may correlate with disease stage. 「Conclusion」：Vascular distribution and properties of endothelial cells appear to be closely associated with progression of cervix neoplasm.
ISSN:1341-7649