Biological analysis of a candidate stem cell -KUSA/A1 cell- for bone tissue engineering

KUSA/A1 cell is a bone marrow stromal cell, capable of differentiating into osteoblasts under inducing conditions. We demonstrated that KUSA/A1 cells with non-osteogenic potential seeded in diffusion chamber differentiated into osteoblasts and produced mineralized bone-like tissue. Finally, we evalu...

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Bibliographic Details
Published in:Journal of Hard Tissue Biology 2007-12, Vol.16 (3), p.150-150
Main Authors: Andrea Paola Rodriguez, Tsujigiwa Hidetsugu, Nagatsuka Hitoshi, Borkosky Silvia, Takagi Tohru, Hailong Hu, Tamamura Ryo, Nagai Noriyuki
Format: Article
Language:eng ; jpn
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Summary:KUSA/A1 cell is a bone marrow stromal cell, capable of differentiating into osteoblasts under inducing conditions. We demonstrated that KUSA/A1 cells with non-osteogenic potential seeded in diffusion chamber differentiated into osteoblasts and produced mineralized bone-like tissue. Finally, we evaluated the effect of honeycomb scaffold to produce abundant bone formation using KUSA/A1 cells implanted in subcutaneous tissues of SCID mice. 1x106 KUSA/A1 cells with honeycomb scaffold showed abundant new bone formation. While, 5x106 KUSA/A1 cells alone showed only few small islands of new bone. This study support that KUSA/A1 cell is a good candidate for basic research in bone tissue engineering.
ISSN:1341-7649