An investigation of the ability to differentiate to dental tissue cells of the bone marrow derived mesenchymal stem cells

We investigated the differentiation ability of the bone marrow derived stem cells, using GFP transgenic mice and rats. Wildtype mice/rats were irradiated (totally 10G) and transplanted GFP mice/rats derived bone marrow cells from caudal vein. After the transplantation, mice/rats were sacrificed and...

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Bibliographic Details
Published in:Journal of Hard Tissue Biology 2007-12, Vol.16 (3), p.151-151
Main Authors: Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Andrea Paola Rodriguez, Hailong Hu, Masao Yamada, Noriyuki Nagai
Format: Article
Language:eng ; jpn
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Summary:We investigated the differentiation ability of the bone marrow derived stem cells, using GFP transgenic mice and rats. Wildtype mice/rats were irradiated (totally 10G) and transplanted GFP mice/rats derived bone marrow cells from caudal vein. After the transplantation, mice/rats were sacrificed and the dental tissues of them were analyzed histologically and biochemically. Immunohistochemically, GFP positive cells were observed in periodontal tissue and dental pulp. In the primary cell culture from these tissues, dominantly proliferated cells were GFP positive and posses calcifying ability. These results suggested that bone marrow derived stem cells may posses differentiation ability to periodontal tissue and odontoblasts.
ISSN:1341-7649