Immunohistochemical analysis of Dkk-3 expression in head and neck squamous cell carcinoma

Previously, we performed genome-wide analysis for the detection of tumor suppressor gene (TSG) in head and neck squamous cell carcinoma (HNSCC). Then we focused on Dkk-3 as a candidate TSG, of which the function was down-regulated in various kinds of tumors. In the present study, we investigated Dkk...

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Main Authors: Masae Fujii, Naoki Katase, Mathieu Lefeuvre, Hidetsugu Tsujigiwa, Midori Kubota, GulSan Ara Sathi, Hiroyuki Matsuda, Hitoshi Nagatsuka
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Language:eng ; jpn
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creator Masae Fujii
Naoki Katase
Mathieu Lefeuvre
Hidetsugu Tsujigiwa
Midori Kubota
GulSan Ara Sathi
Hiroyuki Matsuda
Hitoshi Nagatsuka
description Previously, we performed genome-wide analysis for the detection of tumor suppressor gene (TSG) in head and neck squamous cell carcinoma (HNSCC). Then we focused on Dkk-3 as a candidate TSG, of which the function was down-regulated in various kinds of tumors. In the present study, we investigated Dkk-3 protein expression in HNSCC by immunohistochemistry. Dkk-3 protein expression was observed in the cancer nest and adjacent dysplastic epithelium, normal epithelium and small vessels in various degrees, regardless of TNM stage or histological grading. The results suggest that Dkk-3 protein expression might play an important role in carcinogenesis step of HNSCC.
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identifier ISSN: 1341-7649
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title Immunohistochemical analysis of Dkk-3 expression in head and neck squamous cell carcinoma
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