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Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

[Aim] : Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL) . The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1) , including...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2015, Vol.22 (3), p.313-328
Main Authors: Faruk Turgay, Ali Rlza Sisman, Aylin Cecen Aksu
Format: Article
Language:Japanese
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Summary:[Aim] : Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL) . The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1) , including basal PON1, salt-stimulated PON1 (SPON1) , and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs ; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P) . [Methods] : Our study included 18 Turkish national female judoists (mean age : 17.9+-0.8 years) . Before and after 5 months of anaerobic training, critical speed (CS) , TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG ; persons with low activity) and R carriers (QR+RR) (RG ; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P
ISSN:1340-3478