Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

[Aim] : Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL) . The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1) , including...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2015, Vol.22 (3), p.313-328
Main Authors: Faruk Turgay, Ali Rlza Sisman, Aylin Cecen Aksu
Format: Article
Language:Japanese
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 328
container_issue 3
container_start_page 313
container_title Journal of Atherosclerosis and Thrombosis
container_volume 22
creator Faruk Turgay
Ali Rlza Sisman
Aylin Cecen Aksu
description [Aim] : Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL) . The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1) , including basal PON1, salt-stimulated PON1 (SPON1) , and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs ; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P) . [Methods] : Our study included 18 Turkish national female judoists (mean age : 17.9+-0.8 years) . Before and after 5 months of anaerobic training, critical speed (CS) , TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG ; persons with low activity) and R carriers (QR+RR) (RG ; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P
format article
fullrecord <record><control><sourceid>medicalonline</sourceid><recordid>TN_cdi_medicalonline_journals_ex7domya_2015_002203_012_0313_03282834781</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ex7domya_2015_002203_012_0313_03282834781</sourcerecordid><originalsourceid>FETCH-LOGICAL-m1080-98bacef80455f361b88fe8aedb5058c210df7988d68cf4bdfdd8ed5e4433e2783</originalsourceid><addsrcrecordid>eNotkM1OwkAUhbvQRIK8wyx10WR-WjosCSKQEEHEdTPt3KHXtDNNZ1Drs_iwFnV1zuZ8J_muohETCY1FksmbaOI9FpRyyTmVYhR9L42BMnjiDJlbBZ0rsCTHTqFFeyLOkr3qlPt0VnmIGVnar74BcrffPbF7Mi8DvmNA-N2v8VSRB7AeQ0-22Lq2cwHQkpdzcercufVEWU02w9sBahXQWV9hSz4wVOQCjJ_ZjB_IvgLrQt_CbXRtVO1h8p_j6PVxeVys4-1utVnMt3HDqKTxTBaqBCNpkqZGTFkhpQGpQBcpTWXJGdUmm0mpp7I0SaGN1hJ0CkkiBPBMinG0-uM2oLFUtbM1Wsjf3Lmzw28On5l2Ta9yTlmaD_Y4FTllPKeCDUUMNuVFLxM_GeFv7A</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype</title><source>EZB Electronic Journals Library</source><creator>Faruk Turgay ; Ali Rlza Sisman ; Aylin Cecen Aksu</creator><creatorcontrib>Faruk Turgay ; Ali Rlza Sisman ; Aylin Cecen Aksu ; Ege University School of PhysicalEducation and Sport ; Medical Faculty ; Dokuz Eylul University ; Sports Medicine Private Practice ; Department of Sport Health Sciences ; ozel Saglik LTD. STI ; Biochemistry Department</creatorcontrib><description>[Aim] : Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL) . The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1) , including basal PON1, salt-stimulated PON1 (SPON1) , and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs ; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P) . [Methods] : Our study included 18 Turkish national female judoists (mean age : 17.9+-0.8 years) . Before and after 5 months of anaerobic training, critical speed (CS) , TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG ; persons with low activity) and R carriers (QR+RR) (RG ; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P&lt;=0.05. [Results] : Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. [Conclusions] : Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs-C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research.</description><identifier>ISSN: 1340-3478</identifier><language>jpn</language><publisher>Japan Atherosclerosis Society</publisher><ispartof>Journal of Atherosclerosis and Thrombosis, 2015, Vol.22 (3), p.313-328</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021</link.rule.ids></links><search><creatorcontrib>Faruk Turgay</creatorcontrib><creatorcontrib>Ali Rlza Sisman</creatorcontrib><creatorcontrib>Aylin Cecen Aksu</creatorcontrib><creatorcontrib>Ege University School of PhysicalEducation and Sport</creatorcontrib><creatorcontrib>Medical Faculty</creatorcontrib><creatorcontrib>Dokuz Eylul University</creatorcontrib><creatorcontrib>Sports Medicine Private Practice</creatorcontrib><creatorcontrib>Department of Sport Health Sciences</creatorcontrib><creatorcontrib>ozel Saglik LTD. STI</creatorcontrib><creatorcontrib>Biochemistry Department</creatorcontrib><title>Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype</title><title>Journal of Atherosclerosis and Thrombosis</title><description>[Aim] : Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL) . The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1) , including basal PON1, salt-stimulated PON1 (SPON1) , and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs ; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P) . [Methods] : Our study included 18 Turkish national female judoists (mean age : 17.9+-0.8 years) . Before and after 5 months of anaerobic training, critical speed (CS) , TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG ; persons with low activity) and R carriers (QR+RR) (RG ; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P&lt;=0.05. [Results] : Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. [Conclusions] : Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs-C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research.</description><issn>1340-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNotkM1OwkAUhbvQRIK8wyx10WR-WjosCSKQEEHEdTPt3KHXtDNNZ1Drs_iwFnV1zuZ8J_muohETCY1FksmbaOI9FpRyyTmVYhR9L42BMnjiDJlbBZ0rsCTHTqFFeyLOkr3qlPt0VnmIGVnar74BcrffPbF7Mi8DvmNA-N2v8VSRB7AeQ0-22Lq2cwHQkpdzcercufVEWU02w9sBahXQWV9hSz4wVOQCjJ_ZjB_IvgLrQt_CbXRtVO1h8p_j6PVxeVys4-1utVnMt3HDqKTxTBaqBCNpkqZGTFkhpQGpQBcpTWXJGdUmm0mpp7I0SaGN1hJ0CkkiBPBMinG0-uM2oLFUtbM1Wsjf3Lmzw28On5l2Ta9yTlmaD_Y4FTllPKeCDUUMNuVFLxM_GeFv7A</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Faruk Turgay</creator><creator>Ali Rlza Sisman</creator><creator>Aylin Cecen Aksu</creator><general>Japan Atherosclerosis Society</general><scope/></search><sort><creationdate>2015</creationdate><title>Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype</title><author>Faruk Turgay ; Ali Rlza Sisman ; Aylin Cecen Aksu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-m1080-98bacef80455f361b88fe8aedb5058c210df7988d68cf4bdfdd8ed5e4433e2783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>2015</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Faruk Turgay</creatorcontrib><creatorcontrib>Ali Rlza Sisman</creatorcontrib><creatorcontrib>Aylin Cecen Aksu</creatorcontrib><creatorcontrib>Ege University School of PhysicalEducation and Sport</creatorcontrib><creatorcontrib>Medical Faculty</creatorcontrib><creatorcontrib>Dokuz Eylul University</creatorcontrib><creatorcontrib>Sports Medicine Private Practice</creatorcontrib><creatorcontrib>Department of Sport Health Sciences</creatorcontrib><creatorcontrib>ozel Saglik LTD. STI</creatorcontrib><creatorcontrib>Biochemistry Department</creatorcontrib><jtitle>Journal of Atherosclerosis and Thrombosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faruk Turgay</au><au>Ali Rlza Sisman</au><au>Aylin Cecen Aksu</au><aucorp>Ege University School of PhysicalEducation and Sport</aucorp><aucorp>Medical Faculty</aucorp><aucorp>Dokuz Eylul University</aucorp><aucorp>Sports Medicine Private Practice</aucorp><aucorp>Department of Sport Health Sciences</aucorp><aucorp>ozel Saglik LTD. STI</aucorp><aucorp>Biochemistry Department</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype</atitle><jtitle>Journal of Atherosclerosis and Thrombosis</jtitle><date>2015</date><risdate>2015</risdate><volume>22</volume><issue>3</issue><spage>313</spage><epage>328</epage><pages>313-328</pages><issn>1340-3478</issn><abstract>[Aim] : Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL) . The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1) , including basal PON1, salt-stimulated PON1 (SPON1) , and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs ; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P) . [Methods] : Our study included 18 Turkish national female judoists (mean age : 17.9+-0.8 years) . Before and after 5 months of anaerobic training, critical speed (CS) , TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG ; persons with low activity) and R carriers (QR+RR) (RG ; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P&lt;=0.05. [Results] : Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. [Conclusions] : Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs-C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research.</abstract><pub>Japan Atherosclerosis Society</pub><tpages>16</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1340-3478
ispartof Journal of Atherosclerosis and Thrombosis, 2015, Vol.22 (3), p.313-328
issn 1340-3478
language jpn
recordid cdi_medicalonline_journals_ex7domya_2015_002203_012_0313_03282834781
source EZB Electronic Journals Library
title Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T15%3A26%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-medicalonline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Anaerobic%20Training%20on%20Paraoxonase-1%20Enzyme%20(PON1)%20Activities%20of%20High%20Density%20Lipoprotein%20Subgroups%20and%20Its%20Relationship%20with%20PON1-Q192R%20Phenotype&rft.jtitle=Journal%20of%20Atherosclerosis%20and%20Thrombosis&rft.au=Faruk%20Turgay&rft.aucorp=Ege%20University%20School%20of%20PhysicalEducation%20and%20Sport&rft.date=2015&rft.volume=22&rft.issue=3&rft.spage=313&rft.epage=328&rft.pages=313-328&rft.issn=1340-3478&rft_id=info:doi/&rft_dat=%3Cmedicalonline%3Eex7domya_2015_002203_012_0313_03282834781%3C/medicalonline%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-m1080-98bacef80455f361b88fe8aedb5058c210df7988d68cf4bdfdd8ed5e4433e2783%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true