Association of Left Ventricular Diastolic Dysfunction with Subclinical Coronary Atherosclerotic Disease Burden Using Coronary Artery Calcium Scoring

• Published in: Journal of Atherosclerosis and Thrombosis 2015, Vol.22 (12), p.1278-1286
• Main Authors: Dimitrios Maragiannis, Robert C. Schutt, Nickalaus L. Gramze, Kongkiat Chaikriangkrai, Kelly McGregor, Karen Chin, Faisal Nabi, Stephen H. Little, Sherif F. Nagueh, Su Min Chang
• Format: Article
• Language: Japanese
• ISSN: 1340-3478

[Aim]: Diastolic dysfunction is a common problem in patients with obesity, hypertension, diabetes, or coronary artery disease. The purpose of this study was to evaluate the association of left ventricular diastolic dysfunction with an abnormal coronary artery calcium score (CAC score). [Methods]: This study considered a cohort of patients >- 18 years of age with normal ejection fraction who were admitted to the hospital with chest pain. All patients underwent regadenoson myocardial perfusion stress imaging and had no evidence of ischemia or infarction. Patients then underwent cardiac CT for measurement of CAC score. Patients were excluded if they had prior history of coronary artery disease, ECG findings diagnostic of an acute coronary syndrome, an elevated troponin level, or hemodynamic instability. [Results]: A total of 114 patients were included and 52 (45.6%) patients had echocardiographic evidence of diastolic dysfunction. Patients with diastolic dysfunction were more likely to have an abnormal calcium score (79.6% vs 20%; OR 15.10, 95% CI 5.70 to 43.85; p