Silent ischemia is more prevalent among hypertensive patients with microalbuminuria and salt sensitivity

Some patients with essential hypertension manifest greater than normal urinary albumin excretion (UAE). Salt-sensitive hypertensives also manifest greater UAE compared to salt-resistant individuals. Although the significance of these associations is not well established, several lines of evidence su...

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Bibliographic Details
Published in:Journal of Human Hypertension 2003-01, Vol.17 (1), p.13-20
Main Authors: Bianchi, S, Bigazzi, R, Amoroso, A, Campese, V M
Format: Article
Language:English
Subjects:
Albuminuria
Albuminuria - diagnosis
Albuminuria - epidemiology
Analysis of Variance
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure Monitoring, Ambulatory
Cardiology. Vascular system
Case-Control Studies
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Cohort Studies
Comorbidity
Complications and side effects
Epidemiology
Essential hypertension
Female
Follow-Up Studies
Health Administration
Humans
Hypertension - diagnosis
Hypertension - epidemiology
Ischemia
Kidney Function Tests
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Myocardial Ischemia - diagnosis
Myocardial Ischemia - epidemiology
original-article
Physiological aspects
Prevalence
Probability
Public Health
Reference Values
Risk Assessment
Risk factors
Sensitivity and Specificity
Sodium Chloride, Dietary - adverse effects
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Summary:Some patients with essential hypertension manifest greater than normal urinary albumin excretion (UAE). Salt-sensitive hypertensives also manifest greater UAE compared to salt-resistant individuals. Although the significance of these associations is not well established, several lines of evidence suggest that microalbuminuria and/or salt sensitivity may be associated with greater prevalence of cardiovascular risks and events. In this study, we have evaluated by ergometric exercise 42 subjects with microalbuminuria and 42 matched individuals with normal UAE. All these subjects also underwent a standardized protocol to determine blood pressure sensitivity to a high salt intake. Patients with microalbuminuria displayed greater levels of ambulatory blood pressure and a greater rise in systolic blood pressure during exercise compared to patients with normal UAE (33.1±1.56 vs 26.4±1.7 mmHg, P
ISSN:0950-9240
1476-5381
1476-5527
DOI:10.1038/sj.jhh.1001498