HLA phenotypes as promoters of cardiovascular remodelling in subjects with arterial hypertension

• Published in: Journal of Human Hypertension 2003-01, Vol.17 (1), p.63-68
• Main Authors: Diamantopoulos, E J, Andreadis, E A, Vassilopoulos, C V, Vlachonikolis, I G, Tarassi, K E, Chatzis, N A, Tsourous, G I, Papasteriades, C A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Analysis of Variance; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - genetics; Carotid Artery Diseases - epidemiology; Carotid Artery Diseases - genetics; Case-Control Studies; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Complications and side effects; Diagnosis; Epidemiology; Female; Genetic Markers - genetics; Genetic Predisposition to Disease; Health Administration; Health aspects; Histocompatibility antigens; HLA Antigens - genetics; HLA histocompatibility antigens; Humans; Hypertension; Hypertension - epidemiology; Hypertension - genetics; Hypertrophy, Left Ventricular - epidemiology; Hypertrophy, Left Ventricular - genetics; Incidence; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; original-article; Phenotype; Physiological aspects; Probability; Prognosis; Public Health; Reference Values; Risk Assessment; Risk factors; Sensitivity and Specificity; Tunica Intima - physiopathology; Ventricular Remodeling - physiology
• ISSN: 0950-9240; 1476-5381; 1476-5527
• DOI: 10.1038/sj.jhh.1001502

The objective of this study was to investigate the association between human leukocyte antigens (HLA) phenotypes and cardiovascular remodelling, as expressed by left ventricular mass (LVM) and carotid intima–media thickness (IMT), in hypertensives. We examined 153 subjects with arterial hypertension and 61 normotensive controls living in the greater Athens area. The population was classified into three groups and specifically group I (normotensives), group II with Grade 1 hypertension and group III with Grade 2 or 3 hypertension. HLA class I and class II antigens were studied by microlymphocytotoxic technique. Carotid IMT and LVM were determined by ultrasonography. The prevalence of HLA DQ7 in the hypertensive cohort was 27.4% that was significantly smaller than the 52.5% among the controls ( P =0.002). The HLA DR11 was found in 24.0% of the hypertensives and in 52.5% of the controls ( P