P-110: Cardiovascular risk factors, salt sensitivity and α-adducin polymorphism in venezuelan subjects

• Published in: American journal of hypertension 2003-05, Vol.16 (S1), p.79A-79A
• Main Authors: Castejon, Ana M., Hoffmann, Irene S., Rathinavelu, Appu, Cubeddu, Luigi X.
• Format: Article
• Language: English
• Subjects: alpha-adducin; polymorphism; Salt sentivity
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/S0895-7061(03)00276-0

Human salt sensitivity (SS) most likely results from combined effects of genetic and environmental factors. Several gene candidates have been proposed to determine SS via an effect on renal sodium handling. Gly460Trp polymorphism, which resulted in the genetic variant of amino acid residue 460 of α-adducin protein, has been associated with SS hypertension (HT). However, the results have been controversial. We studied whether α-adducin gene polymorphism (Gly460Trp) was associated with SS, blood pressure (BP), dyslipidemia and other cardiovascular risk factors. A total of 91 healthy adult Venezuelan subjects (Age: 40.3±1.3 y; M/F: 39/52; BMI: 28.9±0.6 kg/m2; SBP/DBP: 119.4±1.8/ 80.0±1.1 mmHg; HR: 65.7±0.9 b/min) were studied. The Gly460Trp mutation was found in 29.7 % of subjects. Compared to the group of subjects carrying the wild type (G/G) gene, those with the G460T mutation had significantly higher BMI (G/T= 30.7±1.1kg and G/G= 28.0±0.6 kg/m2, p