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Intra-uterine transmission of Mycobacterium avium subsp paratuberculosis in subclinically affected red deer (Cervus elaphus)
AIM: To determine the rate of transmission of Mycobacterium avium subsp paratuberculosis (M. ptb) from hind to fetus in utero, and the risk of transmission from dam to fawn via infected colostrum and milk in subclinically affected red deer hinds. METHODS: Hinds were sourced from farms in Otago or So...
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| Published in: | New Zealand veterinary journal 2007-12, Vol.55 (6), p.308-313 |
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| Language: | English |
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| container_end_page | 313 |
| container_issue | 6 |
| container_start_page | 308 |
| container_title | New Zealand veterinary journal |
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| creator | Thompson, BR Clark, RG Mackintosh, CG |
| description | AIM: To determine the rate of transmission of Mycobacterium avium subsp paratuberculosis (M. ptb) from hind to fetus in utero, and the risk of transmission from dam to fawn via infected colostrum and milk in subclinically affected red deer hinds.
METHODS: Hinds were sourced from farms in Otago or Southland and selected for the study if they were positive to the immunoglobulin G1 (IgG1) modified enzyme-linked immunosorbent assay (ELISA) (Paralisa) and exhibited no clinical signs of Johne's disease. The hinds (n=35) were sent to a deer slaughter premises (DSP; n=31) or were killed on-farm (n=4). All post-mortem samples were collected from the fetus first and then from the dam, taking care to avoid cross contamination between samples. Fresh samples (n=185) were collected for culture, and tissue samples (n=72) were collected from 24 hinds and their fetuses for histopathological examination.
RESULTS: A total of 24/35 hinds selected were suitable for inclusion in the study. Eighteen of these pregnant hinds were culture-positive for M. ptb, and 14 of these had culture-positive fetuses, representing a transmission rate of 78% (95% confidence interval (CI) =0.58-0.98) from dam to fetus. Of the 16 mammary glands sampled, 11 (69%) were culture-positive for M. ptb while 12/15 (80%) mammary lymph nodes sampled were also culture-positive.
CONCLUSIONS: This study demonstrated a high rate of transmission of M. ptb from dam to fetus in red deer, and a potential risk of transmission to fawns suckling from mothers that are subclinically affected with Johne's disease. |
| doi_str_mv | 10.1080/00480169.2007.36786 |
| format | article |
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METHODS: Hinds were sourced from farms in Otago or Southland and selected for the study if they were positive to the immunoglobulin G1 (IgG1) modified enzyme-linked immunosorbent assay (ELISA) (Paralisa) and exhibited no clinical signs of Johne's disease. The hinds (n=35) were sent to a deer slaughter premises (DSP; n=31) or were killed on-farm (n=4). All post-mortem samples were collected from the fetus first and then from the dam, taking care to avoid cross contamination between samples. Fresh samples (n=185) were collected for culture, and tissue samples (n=72) were collected from 24 hinds and their fetuses for histopathological examination.
RESULTS: A total of 24/35 hinds selected were suitable for inclusion in the study. Eighteen of these pregnant hinds were culture-positive for M. ptb, and 14 of these had culture-positive fetuses, representing a transmission rate of 78% (95% confidence interval (CI) =0.58-0.98) from dam to fetus. Of the 16 mammary glands sampled, 11 (69%) were culture-positive for M. ptb while 12/15 (80%) mammary lymph nodes sampled were also culture-positive.
CONCLUSIONS: This study demonstrated a high rate of transmission of M. ptb from dam to fetus in red deer, and a potential risk of transmission to fawns suckling from mothers that are subclinically affected with Johne's disease.</description><identifier>ISSN: 0048-0169</identifier><identifier>ISSN: 1176-0710</identifier><identifier>EISSN: 1176-0710</identifier><identifier>DOI: 10.1080/00480169.2007.36786</identifier><identifier>PMID: 18059649</identifier><language>eng</language><publisher>England: Taylor & Francis Group</publisher><subject>Animals ; Cervus elaphus ; Deer ; Deer - microbiology ; Diseases ; Enzyme-Linked Immunosorbent Assay - veterinary ; Female ; Fetus - microbiology ; Immunoglobulin G - blood ; Infectious Disease Transmission, Vertical - veterinary ; intra-uterine transmission ; Johne's disease ; mammary gland ; Milk - microbiology ; Mycobacterium avium subsp. paratuberculosis - isolation & purification ; Mycobacterium paratuberculosis ; New Zealand ; Paratuberculosis - transmission ; Pregnancy ; Pregnancy Complications, Infectious - veterinary ; Red deer ; Veterinary medicine</subject><ispartof>New Zealand veterinary journal, 2007-12, Vol.55 (6), p.308-313</ispartof><rights>Copyright Taylor & Francis Group, LLC 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-8b3a5ce02cae53f9699a2243b3d4547bd8f2f934bdfb8660afcacd03ba38df723</citedby><cites>FETCH-LOGICAL-c386t-8b3a5ce02cae53f9699a2243b3d4547bd8f2f934bdfb8660afcacd03ba38df723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://natlib-primo.hosted.exlibrisgroup.com/primo-explore/search?query=any,contains,995404363602837&tab=innz&search_scope=INNZ&vid=NLNZ&offset=0$$DView this record in NLNZ$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18059649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thompson, BR</creatorcontrib><creatorcontrib>Clark, RG</creatorcontrib><creatorcontrib>Mackintosh, CG</creatorcontrib><title>Intra-uterine transmission of Mycobacterium avium subsp paratuberculosis in subclinically affected red deer (Cervus elaphus)</title><title>New Zealand veterinary journal</title><addtitle>N Z Vet J</addtitle><description>AIM: To determine the rate of transmission of Mycobacterium avium subsp paratuberculosis (M. ptb) from hind to fetus in utero, and the risk of transmission from dam to fawn via infected colostrum and milk in subclinically affected red deer hinds.
METHODS: Hinds were sourced from farms in Otago or Southland and selected for the study if they were positive to the immunoglobulin G1 (IgG1) modified enzyme-linked immunosorbent assay (ELISA) (Paralisa) and exhibited no clinical signs of Johne's disease. The hinds (n=35) were sent to a deer slaughter premises (DSP; n=31) or were killed on-farm (n=4). All post-mortem samples were collected from the fetus first and then from the dam, taking care to avoid cross contamination between samples. Fresh samples (n=185) were collected for culture, and tissue samples (n=72) were collected from 24 hinds and their fetuses for histopathological examination.
RESULTS: A total of 24/35 hinds selected were suitable for inclusion in the study. Eighteen of these pregnant hinds were culture-positive for M. ptb, and 14 of these had culture-positive fetuses, representing a transmission rate of 78% (95% confidence interval (CI) =0.58-0.98) from dam to fetus. Of the 16 mammary glands sampled, 11 (69%) were culture-positive for M. ptb while 12/15 (80%) mammary lymph nodes sampled were also culture-positive.
CONCLUSIONS: This study demonstrated a high rate of transmission of M. ptb from dam to fetus in red deer, and a potential risk of transmission to fawns suckling from mothers that are subclinically affected with Johne's disease.</description><subject>Animals</subject><subject>Cervus elaphus</subject><subject>Deer</subject><subject>Deer - microbiology</subject><subject>Diseases</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>Female</subject><subject>Fetus - microbiology</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious Disease Transmission, Vertical - veterinary</subject><subject>intra-uterine transmission</subject><subject>Johne's disease</subject><subject>mammary gland</subject><subject>Milk - microbiology</subject><subject>Mycobacterium avium subsp. paratuberculosis - isolation & purification</subject><subject>Mycobacterium paratuberculosis</subject><subject>New Zealand</subject><subject>Paratuberculosis - transmission</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - veterinary</subject><subject>Red deer</subject><subject>Veterinary medicine</subject><issn>0048-0169</issn><issn>1176-0710</issn><issn>1176-0710</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kU2r1DAUhoMo3nH0FwgSEEQXHU-bNk03ggx-XLjiRtchnxhJk5o0V0f88abOiDsXyQmc5z0kTxB63MKhBQYvAXoGLZ0OHcB4IHRk9A7ate1IGxhbuIt2G9FsyBV6kPNXADK0hN5HVy2DYaL9tEO_rsOaRFNWk1wwuJ5Dnl3OLgYcLf5wUlEKtXXLjMXttuci84IXkcRapEmq-Jhdxi5sHeVdcEp4f8LCWlOTGqe6tDEJPz-adFsyNl4sX0p-8RDds8Jn8-hS9-jz2zefju-bm4_vro-vbxpFGF0bJokYlIFOCTMQO9FpEl3XE0l0P_Sj1Mx2diK91FYySkFYJZQGIgVh2o4d2aNn57lLit-KySuvT1TGexFMLJnTCXoYq549ImdQpZhzMpYvyc0inXgLfJPO_0rnm3T-R3pNPbmML3I2-l_mYrkCT89A8OEnd0GbH7VO09BDTyih0DEyVurVmXLBxjSL7zF5zVdx8jHZ-i_KZU7-d4_fNd2eqA</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Thompson, BR</creator><creator>Clark, RG</creator><creator>Mackintosh, CG</creator><general>Taylor & Francis Group</general><scope>DUNLO</scope><scope>GOM</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>Intra-uterine transmission of Mycobacterium avium subsp paratuberculosis in subclinically affected red deer (Cervus elaphus)</title><author>Thompson, BR ; Clark, RG ; Mackintosh, CG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-8b3a5ce02cae53f9699a2243b3d4547bd8f2f934bdfb8660afcacd03ba38df723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cervus elaphus</topic><topic>Deer</topic><topic>Deer - microbiology</topic><topic>Diseases</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>Female</topic><topic>Fetus - microbiology</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious Disease Transmission, Vertical - veterinary</topic><topic>intra-uterine transmission</topic><topic>Johne's disease</topic><topic>mammary gland</topic><topic>Milk - microbiology</topic><topic>Mycobacterium avium subsp. paratuberculosis - isolation & purification</topic><topic>Mycobacterium paratuberculosis</topic><topic>New Zealand</topic><topic>Paratuberculosis - transmission</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - veterinary</topic><topic>Red deer</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, BR</creatorcontrib><creatorcontrib>Clark, RG</creatorcontrib><creatorcontrib>Mackintosh, CG</creatorcontrib><collection>Index New Zealand (A&I)</collection><collection>Index New Zealand</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>New Zealand veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, BR</au><au>Clark, RG</au><au>Mackintosh, CG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intra-uterine transmission of Mycobacterium avium subsp paratuberculosis in subclinically affected red deer (Cervus elaphus)</atitle><jtitle>New Zealand veterinary journal</jtitle><addtitle>N Z Vet J</addtitle><date>2007-12</date><risdate>2007</risdate><volume>55</volume><issue>6</issue><spage>308</spage><epage>313</epage><pages>308-313</pages><issn>0048-0169</issn><issn>1176-0710</issn><eissn>1176-0710</eissn><abstract>AIM: To determine the rate of transmission of Mycobacterium avium subsp paratuberculosis (M. ptb) from hind to fetus in utero, and the risk of transmission from dam to fawn via infected colostrum and milk in subclinically affected red deer hinds.
METHODS: Hinds were sourced from farms in Otago or Southland and selected for the study if they were positive to the immunoglobulin G1 (IgG1) modified enzyme-linked immunosorbent assay (ELISA) (Paralisa) and exhibited no clinical signs of Johne's disease. The hinds (n=35) were sent to a deer slaughter premises (DSP; n=31) or were killed on-farm (n=4). All post-mortem samples were collected from the fetus first and then from the dam, taking care to avoid cross contamination between samples. Fresh samples (n=185) were collected for culture, and tissue samples (n=72) were collected from 24 hinds and their fetuses for histopathological examination.
RESULTS: A total of 24/35 hinds selected were suitable for inclusion in the study. Eighteen of these pregnant hinds were culture-positive for M. ptb, and 14 of these had culture-positive fetuses, representing a transmission rate of 78% (95% confidence interval (CI) =0.58-0.98) from dam to fetus. Of the 16 mammary glands sampled, 11 (69%) were culture-positive for M. ptb while 12/15 (80%) mammary lymph nodes sampled were also culture-positive.
CONCLUSIONS: This study demonstrated a high rate of transmission of M. ptb from dam to fetus in red deer, and a potential risk of transmission to fawns suckling from mothers that are subclinically affected with Johne's disease.</abstract><cop>England</cop><pub>Taylor & Francis Group</pub><pmid>18059649</pmid><doi>10.1080/00480169.2007.36786</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0048-0169 |
| ispartof | New Zealand veterinary journal, 2007-12, Vol.55 (6), p.308-313 |
| issn | 0048-0169 1176-0710 1176-0710 |
| language | eng |
| recordid | cdi_nlnz_indexnz_995404363602837 |
| source | Taylor and Francis Science and Technology Collection |
| subjects | Animals Cervus elaphus Deer Deer - microbiology Diseases Enzyme-Linked Immunosorbent Assay - veterinary Female Fetus - microbiology Immunoglobulin G - blood Infectious Disease Transmission, Vertical - veterinary intra-uterine transmission Johne's disease mammary gland Milk - microbiology Mycobacterium avium subsp. paratuberculosis - isolation & purification Mycobacterium paratuberculosis New Zealand Paratuberculosis - transmission Pregnancy Pregnancy Complications, Infectious - veterinary Red deer Veterinary medicine |
| title | Intra-uterine transmission of Mycobacterium avium subsp paratuberculosis in subclinically affected red deer (Cervus elaphus) |
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