Post-vaccinal distemper encephalitis in two Border Collie cross littermates

CASE HISTORY: One 4.5-month-old male Border Collie cross presented with aggression and seizures in October 2006. A 16-month-old, female, spayed Border Collie cross presented with hypersalivation and a dropped jaw and rapidly became stuporous in September 2007. The dogs were littermates and developed...

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Bibliographic Details
Published in:New Zealand veterinary journal 2015-03, Vol.63 (2), p.117-120
Main Authors: Fairley, RA, Knesl, O, Pesavento, PA, Elias, BC
Format: Article
Language:English
Subjects:
aggression
Animals
biological resistance
Border collie
Brain - pathology
brain stem
canine distemper
Canine distemper virus
Collie
Distemper
Distemper - prevention & control
Dog
Dogs
encephalitis
Encephalomyelitis, Acute Disseminated - veterinary
Female
females
histiocytes
histopathology
IHC
Immunization, Secondary - adverse effects
Immunization, Secondary - veterinary
immunohistochemistry
live vaccines
lymphocytes
Male
males
seizures
spaying
vaccination
vaccine
Vaccines
Viral Vaccines - adverse effects
Viral Vaccines - immunology
virulence
viruses
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Summary:CASE HISTORY: One 4.5-month-old male Border Collie cross presented with aggression and seizures in October 2006. A 16-month-old, female, spayed Border Collie cross presented with hypersalivation and a dropped jaw and rapidly became stuporous in September 2007. The dogs were littermates and developed acute neurological signs 5 and 27 days, respectively, after vaccination with different modified live vaccines containing canine distemper virus. HISTOPATHOLOGICAL FINDINGS: Sections of brain in both dogs showed evidence of encephalitis mainly centred on the grey matter of brainstem nuclei, where there was extensive and intense parenchymal and perivascular infiltration of histiocytes and lymphocytes. Intra-nuclear and intra-cytoplasmic inclusions typical of distemper were plentiful and there was abundant labelling for canine distemper virus using immunohistochemistry. DIAGNOSIS: Post-vaccinal canine distemper. CLINCIAL RELEVANCE: Post-vaccinal canine distemper has mainly been attributed to virulent vaccine virus, but it may also occur in dogs whose immunologic nature makes them susceptible to disease induced by a modified-live vaccine virus that is safe and protective for most dogs.
ISSN:1176-0710
0048-0169
1176-0710
DOI:10.1080/00480169.2014.955068