The functional morphology and role of cardiac telocytes in myocardium regeneration

Key morphological discoveries in recent years have included the discovery of new cell populations inside the heart called cardiac telocytes. These newly described cells of the connective tissue have extremely long cytoplasmic processes through which they form functionally connected three-dimensional...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2016-11, Vol.94 (11), p.1117-1121
Main Authors: Varga, Ivan, Danisovic, Lubos, Kyselovic, Jan, Gazova, Andrea, Musil, Peter, Miko, Michal, Polak, Stefan
Format: Article
Language:English
Subjects:
Cells
cellules semblables aux cellules interstitielles de Cajal
Cytoplasm
Functional morphology
Heart
Immune system
interstitial Cajal-like cells
morphologie fonctionnelle
Morphology
myocarde
Myocardium
Physiological aspects
Physiological research
regeneration
Regeneration (Biology)
régénérescence
Stem cells
Studies
telocytes
télocytes
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Summary:Key morphological discoveries in recent years have included the discovery of new cell populations inside the heart called cardiac telocytes. These newly described cells of the connective tissue have extremely long cytoplasmic processes through which they form functionally connected three-dimensional networks that connect cells of the immune system, nerve fibers, cardiac stem cells, and cardiac muscle cells. Based on their functions, telocytes are also referred to as “connecting cells” or “nurse cells” for cardiac progenitor stem cells. In this critical review, we provide a summary of the latest research on cardiac telocytes localized in all layers of the heart — from the historical background of their discovery, through ultrastructural, immunohistochemical, and functional characterizations, to the application of this knowledge to the fields of cardiology, stem cell research, and regenerative medicine.
ISSN:0008-4212
1205-7541
DOI:10.1139/cjpp-2016-0052