Role of catecholamines in the pathogenesis of diabetic cardiomyopathy1

Although the sympathetic nervous system plays an important role in the regulation of cardiac function, the overactivation of the sympathetic nervous system under stressful conditions including diabetes has been shown to result in the excessive production of circulating catecholamines as well as an i...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2019, Vol.97 (9), p.815-819
Main Authors: Dhalla, Naranjan S, Ganguly, Pallab K, Bhullar, Sukhwinder K, Tappia, Paramjit S
Format: Article
Language:English
Subjects:
aminochrome
cardiomyopathie diabétique
catecholamine oxidation products
diabetic cardiomyopathy
oxidative stress
oxyradicals
oxyradicaux
produits de l’oxydation des catécholamines
stress oxydatif
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Summary:Although the sympathetic nervous system plays an important role in the regulation of cardiac function, the overactivation of the sympathetic nervous system under stressful conditions including diabetes has been shown to result in the excessive production of circulating catecholamines as well as an increase in the myocardial concentration of catecholamines. In this brief review, we provide some evidence to suggest that the oxidation products of catecholamines such as aminochrome and oxyradicals, lead to metabolic derangements, Ca 2+ -handling abnormalities, increase in the availability of intracellular free Ca 2+ , as well as activation of proteases and changes in myocardial gene expression. These alterations due to elevated levels of circulatory catecholamines are associated with oxidative stress, subcellular remodeling, and the development of cardiac dysfunction in chronic diabetes.
ISSN:0008-4212
1205-7541
DOI:10.1139/cjpp-2019-0044