A Modified Triester Method for the Synthesis of Deoxyribopolynucleotides

A modified triester method has been developed for the synthesis of oligonucleotides starting from mononucleosides as more economical starting materials. A pentadecanucleotide has been successfully prepared.

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Bibliographic Details
Published in:Canadian journal of chemistry 1973-11, Vol.51 (21), p.3649-3651
Main Authors: Itakura, K, Bahl, C. P, Katagiri, N, Michniewicz, J. J, Wightman, R. H, Narang, S. A
Format: Article
Language:English
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Description
Summary:A modified triester method has been developed for the synthesis of oligonucleotides starting from mononucleosides as more economical starting materials. A pentadecanucleotide has been successfully prepared.
ISSN:0008-4042
1480-3291
DOI:10.1139/v73-543