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Carbon-13 nuclear magnetic resonance studies of the cholesteryl ester - phosphatidylcholine system
Using difference spectroscopy, 13 C spin-lattice relaxation measurements on 40% egg phosphatidylcholine multilamellar liposomes (containing 25 mol% cholesteryl palmitate)-60% D 2 O indicate the ester contributes negligibly to the microviscosity of the acyl chains in the bilayers.At 37 °C, spin-spin...
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| Published in: | Canadian journal of chemistry 1979-09, Vol.57 (18), p.2364-2370 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c136f-c503626f355240ca6b50bf5b6adf3ece49e897b8ca318b9163ee3009ba88826e3 |
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| container_end_page | 2370 |
| container_issue | 18 |
| container_start_page | 2364 |
| container_title | Canadian journal of chemistry |
| container_volume | 57 |
| creator | Cushley, Robert J Forrest, Bruce J |
| description | Using difference spectroscopy,
13
C spin-lattice relaxation measurements on 40% egg phosphatidylcholine multilamellar liposomes (containing 25 mol% cholesteryl palmitate)-60% D
2
O indicate the ester contributes negligibly to the microviscosity of the acyl chains in the bilayers.At 37 °C, spin-spin and spin-lattice relaxation measurements have been obtained for 25 mol% cholesteryl linoleate in both egg phosphatidylcholine and dipalmitoyl phosphatidylcholine multilayers and indicate: (a) T
1
values of the linoleate ester chain are 0.5 times those of the lecithin chain carbons, and (b) T
2
* = 16 ± 6 ms for all discernable linoleate carbons. At 52 °C, cholesteryl ring carbons C5 and C6 yield T
2
* values of 23 and 20 ms, respectively. These studies suggest the esters reside in an environment whose "fluidity" approaches that found in very low density lipoprotein (VLDL). |
| doi_str_mv | 10.1139/v79-380 |
| format | article |
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13
C spin-lattice relaxation measurements on 40% egg phosphatidylcholine multilamellar liposomes (containing 25 mol% cholesteryl palmitate)-60% D
2
O indicate the ester contributes negligibly to the microviscosity of the acyl chains in the bilayers.At 37 °C, spin-spin and spin-lattice relaxation measurements have been obtained for 25 mol% cholesteryl linoleate in both egg phosphatidylcholine and dipalmitoyl phosphatidylcholine multilayers and indicate: (a) T
1
values of the linoleate ester chain are 0.5 times those of the lecithin chain carbons, and (b) T
2
* = 16 ± 6 ms for all discernable linoleate carbons. At 52 °C, cholesteryl ring carbons C5 and C6 yield T
2
* values of 23 and 20 ms, respectively. These studies suggest the esters reside in an environment whose "fluidity" approaches that found in very low density lipoprotein (VLDL).</description><identifier>ISSN: 0008-4042</identifier><identifier>EISSN: 1480-3291</identifier><identifier>DOI: 10.1139/v79-380</identifier><language>eng</language><publisher>Ottawa, Canada: NRC Research Press</publisher><ispartof>Canadian journal of chemistry, 1979-09, Vol.57 (18), p.2364-2370</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c136f-c503626f355240ca6b50bf5b6adf3ece49e897b8ca318b9163ee3009ba88826e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Cushley, Robert J</creatorcontrib><creatorcontrib>Forrest, Bruce J</creatorcontrib><title>Carbon-13 nuclear magnetic resonance studies of the cholesteryl ester - phosphatidylcholine system</title><title>Canadian journal of chemistry</title><addtitle>Revue canadienne de chimie</addtitle><description>Using difference spectroscopy,
13
C spin-lattice relaxation measurements on 40% egg phosphatidylcholine multilamellar liposomes (containing 25 mol% cholesteryl palmitate)-60% D
2
O indicate the ester contributes negligibly to the microviscosity of the acyl chains in the bilayers.At 37 °C, spin-spin and spin-lattice relaxation measurements have been obtained for 25 mol% cholesteryl linoleate in both egg phosphatidylcholine and dipalmitoyl phosphatidylcholine multilayers and indicate: (a) T
1
values of the linoleate ester chain are 0.5 times those of the lecithin chain carbons, and (b) T
2
* = 16 ± 6 ms for all discernable linoleate carbons. At 52 °C, cholesteryl ring carbons C5 and C6 yield T
2
* values of 23 and 20 ms, respectively. These studies suggest the esters reside in an environment whose "fluidity" approaches that found in very low density lipoprotein (VLDL).</description><issn>0008-4042</issn><issn>1480-3291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LxDAQxYMouK7iV8hJQYhOmjabHGXxHyx40XNJshNb6aYl6Qr99mbdxYPgaRjeb97wHiGXHG45F_rua6GZUHBEZrxUwESh-TGZAYBiJZTFKTlL6TOvCyiqGbFLE20fGBc0bF2HJtKN-Qg4to5GTH0wwSFN43bdYqK9p2OD1DV9h2nEOHX0Z1JGh6ZPQ2PGdj11O70N-WzK4uacnHjTJbw4zDl5f3x4Wz6z1evTy_J-xRwX0jNXgZCF9KKqihKckbYC6ysrzdoLdFhqVHphlTOCK6u5FIgCQFujlCokijm53vu62KcU0ddDbDcmTjWHeldNnaupczWZvNqTIbocMod2zS98gOohv52Tm__Bv67fIIhzew</recordid><startdate>19790915</startdate><enddate>19790915</enddate><creator>Cushley, Robert J</creator><creator>Forrest, Bruce J</creator><general>NRC Research Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19790915</creationdate><title>Carbon-13 nuclear magnetic resonance studies of the cholesteryl ester - phosphatidylcholine system</title><author>Cushley, Robert J ; Forrest, Bruce J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c136f-c503626f355240ca6b50bf5b6adf3ece49e897b8ca318b9163ee3009ba88826e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cushley, Robert J</creatorcontrib><creatorcontrib>Forrest, Bruce J</creatorcontrib><collection>CrossRef</collection><jtitle>Canadian journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cushley, Robert J</au><au>Forrest, Bruce J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbon-13 nuclear magnetic resonance studies of the cholesteryl ester - phosphatidylcholine system</atitle><jtitle>Canadian journal of chemistry</jtitle><addtitle>Revue canadienne de chimie</addtitle><date>1979-09-15</date><risdate>1979</risdate><volume>57</volume><issue>18</issue><spage>2364</spage><epage>2370</epage><pages>2364-2370</pages><issn>0008-4042</issn><eissn>1480-3291</eissn><abstract>Using difference spectroscopy,
13
C spin-lattice relaxation measurements on 40% egg phosphatidylcholine multilamellar liposomes (containing 25 mol% cholesteryl palmitate)-60% D
2
O indicate the ester contributes negligibly to the microviscosity of the acyl chains in the bilayers.At 37 °C, spin-spin and spin-lattice relaxation measurements have been obtained for 25 mol% cholesteryl linoleate in both egg phosphatidylcholine and dipalmitoyl phosphatidylcholine multilayers and indicate: (a) T
1
values of the linoleate ester chain are 0.5 times those of the lecithin chain carbons, and (b) T
2
* = 16 ± 6 ms for all discernable linoleate carbons. At 52 °C, cholesteryl ring carbons C5 and C6 yield T
2
* values of 23 and 20 ms, respectively. These studies suggest the esters reside in an environment whose "fluidity" approaches that found in very low density lipoprotein (VLDL).</abstract><cop>Ottawa, Canada</cop><pub>NRC Research Press</pub><doi>10.1139/v79-380</doi><tpages>7</tpages></addata></record> |
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| ispartof | Canadian journal of chemistry, 1979-09, Vol.57 (18), p.2364-2370 |
| issn | 0008-4042 1480-3291 |
| language | eng |
| recordid | cdi_nrcresearch_primary_10_1139_v79_380 |
| source | EZB Free E-Journals |
| title | Carbon-13 nuclear magnetic resonance studies of the cholesteryl ester - phosphatidylcholine system |
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