Tissue elastance influences airway smooth muscle shortening: comparison of mechanical properties among different species

We have observed striking differences in the mechanical properties of airway smooth muscle preparations among different species. In this study, we provide a novel analysis on the influence of tissue elastance on smooth muscle shortening using previously published data from our laboratory. We have fo...

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Published in:Canadian journal of physiology and pharmacology 2002-09, Vol.80 (9), p.865-871
Main Authors: Saez, Anabelle M. Opazo, Schellenberg, R Robert, Ludwig, Mara S, Meiss, Richard A, Paré, Peter D
Format: Article
Language:English
Subjects:
Animals
Biomechanical Phenomena
Bronchi - physiology
Dogs
Elasticity
Humans
In Vitro Techniques
Muscle Contraction - physiology
Muscle, Smooth - physiology
Muscles
Rabbits
Species Specificity
Swine
Throat
Trachea - physiology
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cited_by cdi_FETCH-LOGICAL-c370t-d837d9e51edfea56a5fd4527d4d021aa97cce26205690a33056524b510c50e013
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container_title Canadian journal of physiology and pharmacology
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creator Saez, Anabelle M. Opazo
Schellenberg, R Robert
Ludwig, Mara S
Meiss, Richard A
Paré, Peter D
description We have observed striking differences in the mechanical properties of airway smooth muscle preparations among different species. In this study, we provide a novel analysis on the influence of tissue elastance on smooth muscle shortening using previously published data from our laboratory. We have found that isolated human airways exhibit substantial passive tension in contrast to airways from the dog and pig, which exhibit little passive tension (
doi_str_mv 10.1139/y02-112
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Opazo ; Schellenberg, R Robert ; Ludwig, Mara S ; Meiss, Richard A ; Paré, Peter D</creator><creatorcontrib>Saez, Anabelle M. Opazo ; Schellenberg, R Robert ; Ludwig, Mara S ; Meiss, Richard A ; Paré, Peter D</creatorcontrib><description>We have observed striking differences in the mechanical properties of airway smooth muscle preparations among different species. In this study, we provide a novel analysis on the influence of tissue elastance on smooth muscle shortening using previously published data from our laboratory. We have found that isolated human airways exhibit substantial passive tension in contrast to airways from the dog and pig, which exhibit little passive tension (&lt;5% of maximal active force versus ~60% for human bronchi). In the dog and pig, airway preparations shorten up to 70% from L max (the length at which maximal active force occurs), whereas human airways shorten by only ~12% from L max . Isolated airways from the rabbit exhibit relatively low passive tension (~22% F max ) and shorten by 60% from L max . Morphologic evaluation of airway cross sections revealed that 25-35% of the airway wall is muscle in canine, porcine, and rabbit airways in contrast to ~9% in human airway preparations. We postulate that the large passive tension needed to stretch the muscle to L max reflects the high connective tissue content surrounding the smooth muscle, which limits shortening during smooth muscle contraction by imposing an elastic load, as well as by causing radial constraint.Key words: isometric force, isotonic shortening, elastance.</description><identifier>ISSN: 0008-4212</identifier><identifier>EISSN: 1205-7541</identifier><identifier>DOI: 10.1139/y02-112</identifier><identifier>PMID: 12430981</identifier><identifier>CODEN: CJPPA3</identifier><language>eng</language><publisher>Ottawa, Canada: NRC Research Press</publisher><subject>Animals ; Biomechanical Phenomena ; Bronchi - physiology ; Dogs ; Elasticity ; Humans ; In Vitro Techniques ; Muscle Contraction - physiology ; Muscle, Smooth - physiology ; Muscles ; Rabbits ; Species Specificity ; Swine ; Throat ; Trachea - physiology</subject><ispartof>Canadian journal of physiology and pharmacology, 2002-09, Vol.80 (9), p.865-871</ispartof><rights>Copyright National Research Council of Canada Sep 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-d837d9e51edfea56a5fd4527d4d021aa97cce26205690a33056524b510c50e013</citedby><cites>FETCH-LOGICAL-c370t-d837d9e51edfea56a5fd4527d4d021aa97cce26205690a33056524b510c50e013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12430981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saez, Anabelle M. 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subjects Animals
Biomechanical Phenomena
Bronchi - physiology
Dogs
Elasticity
Humans
In Vitro Techniques
Muscle Contraction - physiology
Muscle, Smooth - physiology
Muscles
Rabbits
Species Specificity
Swine
Throat
Trachea - physiology
title Tissue elastance influences airway smooth muscle shortening: comparison of mechanical properties among different species
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