Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2

The proglucagon-derived peptide family consists of three highly related peptides, glucagon and the glucagon-like peptides GLP-1 and GLP-2. Although the biological activity of glucagon as a counter-regulatory hormone has been known for almost a century, studies conducted over the past decade have now...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2003-11, Vol.81 (11), p.1005-1012
Main Authors: Brubaker, Patricia L, Anini, Younes
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gastrointestinal hormones
Gastrointestinal tract
Glucagon - secretion
Glucagon-Like Peptide 1
Glucagon-Like Peptide 2
Hormones
Humans
Intestinal Mucosa - secretion
Neurons
Nutrition
Peptide Fragments - secretion
Peptides
Peptides - secretion
Protein Precursors - secretion
Vagus Nerve - secretion
Vertebrates: digestive system
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Summary:The proglucagon-derived peptide family consists of three highly related peptides, glucagon and the glucagon-like peptides GLP-1 and GLP-2. Although the biological activity of glucagon as a counter-regulatory hormone has been known for almost a century, studies conducted over the past decade have now also elucidated important roles for GLP-1 as an antidiabetic hormone, and for GLP-2 as a stimulator of intestinal growth. In contrast to pancreatic glucagon, the GLPs are synthesized in the intestinal epithelial L cells, where they are subject to the influences of luminal nutrients, as well as to a variety of neuroendocrine inputs. In this review, we will focus on the complex integrative mechanisms that regulate the secretion of these peptides from L cells, including both direct and indirect regulation by ingested nutrients.Key words: GLP-1, GLP-2, intestine, secretion, nutrients, neural.
ISSN:0008-4212
1205-7541
DOI:10.1139/y03-107