Preoperative lymphocyte-to-C-reactive protein ratio predicts hepatocellular carcinoma recurrence after surgery

PurposeThis study was performed to determine the prognostic value of lymphocyte-to-CRP ratio after curative resection for hepatocellular carcinoma. MethodsBetween July 2010 and October 2021, 173 consecutive patients (144 male, 29 female) who underwent surgical resection for pathologically confirmed...

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Published in:Annals of surgical treatment and research 2022, 103(2), , pp.72-80
Main Authors: Utsumi, Masashi, Inagaki, Masaru, Kitada, Koji, Tokunaga, Naoyuki, Kondo, Midori, Sakurai, Yuya, Yunoki, Kosuke, Hamano, Ryosuke, Miyasou, Hideaki, Tsunemitsu, Yousuke, Otsuka, Shinya
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일반외과학
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container_title Annals of surgical treatment and research
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creator Utsumi, Masashi
Inagaki, Masaru
Kitada, Koji
Tokunaga, Naoyuki
Kondo, Midori
Sakurai, Yuya
Yunoki, Kosuke
Hamano, Ryosuke
Miyasou, Hideaki
Tsunemitsu, Yousuke
Otsuka, Shinya
description PurposeThis study was performed to determine the prognostic value of lymphocyte-to-CRP ratio after curative resection for hepatocellular carcinoma. MethodsBetween July 2010 and October 2021, 173 consecutive patients (144 male, 29 female) who underwent surgical resection for pathologically confirmed hepatocellular carcinoma were included in this retrospective study. Cox regression analysis was used to evaluate the relationship between clinicopathological characteristics and recurrence-free survival (RFS) and overall survival (OS). A P-value of
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MethodsBetween July 2010 and October 2021, 173 consecutive patients (144 male, 29 female) who underwent surgical resection for pathologically confirmed hepatocellular carcinoma were included in this retrospective study. Cox regression analysis was used to evaluate the relationship between clinicopathological characteristics and recurrence-free survival (RFS) and overall survival (OS). A P-value of &lt;0.05 was considered statistically significant. ResultsThe patients (mean age, 71 years) were stratified into high (≥9,500, n = 108) and low (&lt;9,500, n = 65) lymphocyte-to-CRP ratio groups. The low lymphocyte-to-CRP ratio group had significantly worse RFS and OS. Low lymphocyte-to-CRP ratio (hazard ratio [HR], 1.865; 95% confidence interval [CI], 1.176-2.960; P = 0.008), multiple tumors (HR, 3.333; 95% CI, 2.042-5.343; P &lt; 0.001), and microvascular invasion (HR, 1.934; 95% CI, 1.178-3.184; P = 0.009) were independently associated with RFS, whereas low albumin-to-globulin ratio (HR, 2.270; 95% CI, 1.074-4.868; P = 0.032), α-FP of ≥25 ng/mL (HR, 2.187; 95% CI, 1.115-4.259; P = 0.023), and poor tumor differentiation (HR, 2.781; 95% CI, 1.041-6.692; P = 0.042) were independently associated with OS. Lymphocyte-to-CRP ratio had a higher area under the curve (0.635) than other inflammation-based markers (0.51-0.63). ConclusionLymphocyte-to-CRP ratio is superior to other inflammation-based markers as a predictor of RFS in patients with surgically resected hepatocellular carcinoma.</description><identifier>ISSN: 2288-6575</identifier><identifier>EISSN: 2288-6796</identifier><identifier>DOI: 10.4174/astr.2022.103.2.72</identifier><identifier>PMID: 36017137</identifier><language>eng</language><publisher>대한외과학회</publisher><subject>Original ; 일반외과학</subject><ispartof>Annals of Surgical Treatment and Research, 2022, 103(2), , pp.72-80</ispartof><rights>Copyright © 2022, the Korean Surgical Society 2022 The Korean Surgical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-9d499e6ae2598177e22e798a2f954a0b2bb28c2f6d660bfc254b53a2ac3ed3853</citedby><cites>FETCH-LOGICAL-c444t-9d499e6ae2598177e22e798a2f954a0b2bb28c2f6d660bfc254b53a2ac3ed3853</cites><orcidid>0000-0003-4414-0112 ; 0000-0003-0501-026X ; 0000-0002-3342-9415 ; 0000-0001-9821-0169 ; 0000-0001-8049-2858 ; 0000-0002-5966-6718 ; 0000-0002-0358-3075 ; 0000-0002-1219-0273 ; 0000-0001-5522-8596 ; 0000-0002-9294-0651 ; 0000-0002-7659-7291</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365642/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365642/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002865346$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Utsumi, Masashi</creatorcontrib><creatorcontrib>Inagaki, Masaru</creatorcontrib><creatorcontrib>Kitada, Koji</creatorcontrib><creatorcontrib>Tokunaga, Naoyuki</creatorcontrib><creatorcontrib>Kondo, Midori</creatorcontrib><creatorcontrib>Sakurai, Yuya</creatorcontrib><creatorcontrib>Yunoki, Kosuke</creatorcontrib><creatorcontrib>Hamano, Ryosuke</creatorcontrib><creatorcontrib>Miyasou, Hideaki</creatorcontrib><creatorcontrib>Tsunemitsu, Yousuke</creatorcontrib><creatorcontrib>Otsuka, Shinya</creatorcontrib><title>Preoperative lymphocyte-to-C-reactive protein ratio predicts hepatocellular carcinoma recurrence after surgery</title><title>Annals of surgical treatment and research</title><description>PurposeThis study was performed to determine the prognostic value of lymphocyte-to-CRP ratio after curative resection for hepatocellular carcinoma. MethodsBetween July 2010 and October 2021, 173 consecutive patients (144 male, 29 female) who underwent surgical resection for pathologically confirmed hepatocellular carcinoma were included in this retrospective study. Cox regression analysis was used to evaluate the relationship between clinicopathological characteristics and recurrence-free survival (RFS) and overall survival (OS). A P-value of &lt;0.05 was considered statistically significant. ResultsThe patients (mean age, 71 years) were stratified into high (≥9,500, n = 108) and low (&lt;9,500, n = 65) lymphocyte-to-CRP ratio groups. The low lymphocyte-to-CRP ratio group had significantly worse RFS and OS. Low lymphocyte-to-CRP ratio (hazard ratio [HR], 1.865; 95% confidence interval [CI], 1.176-2.960; P = 0.008), multiple tumors (HR, 3.333; 95% CI, 2.042-5.343; P &lt; 0.001), and microvascular invasion (HR, 1.934; 95% CI, 1.178-3.184; P = 0.009) were independently associated with RFS, whereas low albumin-to-globulin ratio (HR, 2.270; 95% CI, 1.074-4.868; P = 0.032), α-FP of ≥25 ng/mL (HR, 2.187; 95% CI, 1.115-4.259; P = 0.023), and poor tumor differentiation (HR, 2.781; 95% CI, 1.041-6.692; P = 0.042) were independently associated with OS. Lymphocyte-to-CRP ratio had a higher area under the curve (0.635) than other inflammation-based markers (0.51-0.63). 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MethodsBetween July 2010 and October 2021, 173 consecutive patients (144 male, 29 female) who underwent surgical resection for pathologically confirmed hepatocellular carcinoma were included in this retrospective study. Cox regression analysis was used to evaluate the relationship between clinicopathological characteristics and recurrence-free survival (RFS) and overall survival (OS). A P-value of &lt;0.05 was considered statistically significant. ResultsThe patients (mean age, 71 years) were stratified into high (≥9,500, n = 108) and low (&lt;9,500, n = 65) lymphocyte-to-CRP ratio groups. The low lymphocyte-to-CRP ratio group had significantly worse RFS and OS. Low lymphocyte-to-CRP ratio (hazard ratio [HR], 1.865; 95% confidence interval [CI], 1.176-2.960; P = 0.008), multiple tumors (HR, 3.333; 95% CI, 2.042-5.343; P &lt; 0.001), and microvascular invasion (HR, 1.934; 95% CI, 1.178-3.184; P = 0.009) were independently associated with RFS, whereas low albumin-to-globulin ratio (HR, 2.270; 95% CI, 1.074-4.868; P = 0.032), α-FP of ≥25 ng/mL (HR, 2.187; 95% CI, 1.115-4.259; P = 0.023), and poor tumor differentiation (HR, 2.781; 95% CI, 1.041-6.692; P = 0.042) were independently associated with OS. Lymphocyte-to-CRP ratio had a higher area under the curve (0.635) than other inflammation-based markers (0.51-0.63). ConclusionLymphocyte-to-CRP ratio is superior to other inflammation-based markers as a predictor of RFS in patients with surgically resected hepatocellular carcinoma.</abstract><pub>대한외과학회</pub><pmid>36017137</pmid><doi>10.4174/astr.2022.103.2.72</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4414-0112</orcidid><orcidid>https://orcid.org/0000-0003-0501-026X</orcidid><orcidid>https://orcid.org/0000-0002-3342-9415</orcidid><orcidid>https://orcid.org/0000-0001-9821-0169</orcidid><orcidid>https://orcid.org/0000-0001-8049-2858</orcidid><orcidid>https://orcid.org/0000-0002-5966-6718</orcidid><orcidid>https://orcid.org/0000-0002-0358-3075</orcidid><orcidid>https://orcid.org/0000-0002-1219-0273</orcidid><orcidid>https://orcid.org/0000-0001-5522-8596</orcidid><orcidid>https://orcid.org/0000-0002-9294-0651</orcidid><orcidid>https://orcid.org/0000-0002-7659-7291</orcidid><oa>free_for_read</oa></addata></record>
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일반외과학
title Preoperative lymphocyte-to-C-reactive protein ratio predicts hepatocellular carcinoma recurrence after surgery
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