Radiographic changes of mandibular cortical bone in bisphosphonate drug holiday

ObjectivesThere have been few studies to date on the residual effect of bisphosphonate. This study investigated the radiographic changes of mandibular cortical thickness upon bisphosphonate drug holiday. Materials and MethodsThis retrospective study includes 36 patients diagnosed with MRONJ (medicat...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Korean Association of Oral and Maxillofacial Surgeons 2022, 48(4), , pp.219-224
Main Authors: Lee, Dae-Hoon, Seo, Ja-In, Song, Seung-Il, Lee, Jeong-Keun
Format: Article
Language:English
Subjects:
Original
치의학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ObjectivesThere have been few studies to date on the residual effect of bisphosphonate. This study investigated the radiographic changes of mandibular cortical thickness upon bisphosphonate drug holiday. Materials and MethodsThis retrospective study includes 36 patients diagnosed with MRONJ (medication-related osteonecrosis of the jaw) at Ajou University Dental Hospital in 2010-2021. All patients stopped taking bisphosphonate under consultation with the prescribing physicians. Panoramic radiographs were taken at the start of discontinuation (T0), 12 months after (T1), and 18 months after (T2) discontinuation of bisphosphonate, respectively. Mental index and panoramic mandibular index were calculated using Ledgerton's method. Paired t-tests were used to analyze differences over time. ResultsThe difference in indices (mental index and panoramic mandibular index) between T0 and T1 was not statistically significant (paired t-test, P>0.05). However, the difference in these indices between T1 and T2 was statistically significant (paired t-test, P
ISSN:2234-7550
2234-5930
DOI:10.5125/jkaoms.2022.48.4.219