Treatment of Atopic Dermatitis Associated with Malassezia sympodialis by Green Tea Extracts Bath Therapy: A Pilot Study

Multiple treatment modalities, including topical and systemic corticosteroid and phototherapy, have been used in treatment of patients with atopic dermatitis. However, long-term corticosteroid therapy may have various adverse effects. The purpose of this study was to investigate the therapeutic effi...

Full description

Saved in:
Bibliographic Details
Published in:Mycobiology 2012, 40(2), , pp.124-128
Main Authors: Kim, H.K., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Chang, H.K., AmorePacific RnD Center, Yongin, Republic of Korea, Baek, S.Y., AmorePacific RnD Center, Yongin, Republic of Korea, Chung, J.O., AmorePacific RnD Center, Yongin, Republic of Korea, Rha, C.S., AmorePacific RnD Center, Yongin, Republic of Korea, Kim, S.Y., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Kim, B.J., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Kim, M.N., Chung-Ang University College of Medicine, Seoul, Republic of Korea
Format: Article
Language:English
Subjects:
Atopic dermatitis
Bath therapy
CATECHIN
CATECHINE
CATEQUINA
Green tea extract
생물학
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multiple treatment modalities, including topical and systemic corticosteroid and phototherapy, have been used in treatment of patients with atopic dermatitis. However, long-term corticosteroid therapy may have various adverse effects. The purpose of this study was to investigate the therapeutic efficacy and safety of bath therapy using green tea extracts for treatment of patients with atopic dermatitis. A total of four patients with atopic dermatitis were enrolled in this study. A Malassezia multiplex detection kit was used in performance of multiplex PCR on clinical isolates, which confirmed Malassezia sympodialis. Subjects underwent treatment with bath therapy using green tea extracts three times per wk for a period of 4 wk. Assessment using the scoring atopic dermatitis (SCORAD) index, the visual analogue scale for pruritus, and transepidermal water loss was performed weekly. Laboratory tests were performed before and after treatment. All patients showed marked improvement on the mean SCORAD and visual analogue scale, and a significant decrease in the mean values of serum eosinophil counts was observed after treatment. Bath therapy with green tea extract is an effective, safe, and nonsteroidal therapy for treatment of patients with atopic dermatitis associated with Malassezia sympodialis.
ISSN:1229-8093
2092-9323
DOI:10.5941/MYCO.2012.40.2.124