The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells

We examined the neuroprotective and neurotrophic effects of Tremella fuciformis. The neurotrophic effects of the hot water extract of T. fuciformis was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells. The hot water extract of T. fuciformis promoted neur...

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Published in:Mycobiology 2007, 35(1), , pp.11-15
Main Authors: Park, K.J. (Pulmuone Co., Ltd., Seoul, Republic of Korea), Lee, S.Y. (Pulmuone Co., Ltd., Seoul, Republic of Korea), Kim, H.S. (Kyungnam University, Masan, Republic of Korea), Yamazaki, Matsumi (Hokuriku University, Kanazawa, Ishikawa, Japan), Chiba, Kenzo (Hokuriku University, Kanazawa, Ishikawa, Japan), Ha, H.C. (Pulmuone Co., Ltd., Seoul, Republic of Korea), E-mail: hcha@pulmuone.co.kr
Format: Article
Language:English
Subjects:
CELLS
CELLULE
CELULAS
Neuroprotective effect
Neurotrophic effect
PC12h cell
Tremella fuciformis
생물학
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Summary:We examined the neuroprotective and neurotrophic effects of Tremella fuciformis. The neurotrophic effects of the hot water extract of T. fuciformis was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells. The hot water extract of T. fuciformis promoted neurite outgrowth in PC12h cells in this study, superior to other natural substances which was reported previously. When cells were treated with the hot water extract of T. fuciformis prior to β-amyloid peptide treatment (active domain of A peptide 25~35 treated), toxicity was significantly diminished (p less than 0.01). These results suggest that T. fuciformis might potentially be used as a precautionary agent in neurodegenerative disease, such as Alzheimer's disease, etc.
ISSN:1229-8093
2092-9323
DOI:10.4489/MYCO.2007.35.1.011