Loading…
Subchronic Oral Dose Toxicity of Freeze-dried Powder of Allomyrina dichotoma Larvae
The objective of this study was to investigate the toxicological information of freeze-dried powder from Allomyrina dichotoma ( A. dichotoma ) larvae as a food ingredient. The powder, suspended in distilled water, was administered once daily by oral gavage to four groups of Sprague-Dawley (SD) rats...
Saved in:
Published in: | Toxicological research (Seoul) 2015, 31(1), , pp.69-75 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The objective of this study was to investigate the toxicological information of freeze-dried powder from
Allomyrina dichotoma
(
A. dichotoma
) larvae as a food ingredient. The powder, suspended in distilled water, was administered once daily by oral gavage to four groups of Sprague-Dawley (SD) rats at dose levels of 0 (vehicle control), 250, 850, and 2500 mg/kg/day. After 13 wks of repeated administration, the standard toxicological parameters such as mortality, clinical signs, body weight, food consumption, ophthalmologic examination, clinical pathology, organ weights and macro/microscopic examination were applied for assessment of general toxicity. In addition, serum IgE and histamine levels were determined to evaluate allergenicity. The freeze-dried powder from
A
.
dichotoma
larvae did not produce treatmentrelated changes or findings in any toxicological parameters in either sex of any dosed groups except for slight increases in serum histamine levels at 2500 mg/kg/day. The changes were considered not to be adverse since the magnitude was minimal. In conclusion, the NOAEL (No Observed Adverse Effect Level) of the freeze-dried powder from
A. dichotoma
larvae was determined to be 2500 mg/kg/day or more in both sexes of SD rats and it is considered a candidate to be edible material. |
---|---|
ISSN: | 1976-8257 2234-2753 |
DOI: | 10.5487/TR.2015.31.1.069 |