Safety Evaluation of Topical Valproate Application

The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study, we investigated whether VPA causes skin irritation in humans. We first performed a cell viability test and...

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Published in:Toxicological research (Seoul) 2013, 29(2), , pp.87-90
Main Authors: Choi, S.Y., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Seop, S.Y., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Hyun, M.Y., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Yoo, K.H., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Kim, B.J., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Kim, M.N., Chung-Ang University College of Medicine, Seoul, Republic of Korea, Cho, J.W., Keimyung University School of Medicine, Daegu, Republic of Korea
Format: Article
Language:English
Subjects:
Biomedicine
EVALUACION
EVALUATION
Pharmacology/Toxicology
Valproate,Skin toxicity
예방의학
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Summary:The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study, we investigated whether VPA causes skin irritation in humans. We first performed a cell viability test and showed that VPA did not exhibit toxicity toward HaCaT keratinocytes, fibroblasts, and RBL-3H mast cells. We then performed clinical patch test and skin irritation test through transdermal drug delivery with the help of microneedle rollers. No significant findings were obtained in the clinical patch test. In the skin irritation test, only 1 patient showed erythema at 1 hr, but the irritation reaction faded away within a few hours. Erythema and edema were not observed at 24 hr. We concluded that VPA has minimal potential to elicit skin irritation. Therefore, we consider that VPA can safely be applied to human skin.
ISSN:1976-8257
2234-2753
DOI:10.5487/TR.2013.29.2.087