Loading…
Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study
The estimated glomerular filtration rate (eGFR) at 6 months after donation (eGFR ) is strongly associated with the risk of end-stage renal disease in living kidney donors. This study aimed to investigate the incidence of eGFR
Saved in:
| Published in: | Yonsei medical journal 2023, 64(3), , pp.221-227 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c378t-6053d0f2223f9f352ed5b8f4c535d702809c28b9dbeb156736c1f877d37dfb943 |
| container_end_page | 227 |
| container_issue | 3 |
| container_start_page | 221 |
| container_title | Yonsei medical journal |
| container_volume | 64 |
| creator | Park, Jin Ha Kim, So Yeon Cho, Jin Sun Shin, Dongkwan Ham, Sung Yeon Kim, Hyesu Kwak, Young-Lan |
| description | The estimated glomerular filtration rate (eGFR) at 6 months after donation (eGFR
) is strongly associated with the risk of end-stage renal disease in living kidney donors. This study aimed to investigate the incidence of eGFR |
| doi_str_mv | 10.3349/ymj.2022.0541 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_10123012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2780069361</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-6053d0f2223f9f352ed5b8f4c535d702809c28b9dbeb156736c1f877d37dfb943</originalsourceid><addsrcrecordid>eNpVkUtvEzEUhS0EoiGwZIu8REgT_JgZj1kgRaUpFUFUpaytGT9atzN2sD2p8kP6f_EkoYKFdWWdc7_r6wPAW4wWlJb84264WxBEyAJVJX4GZpizuiAlZc_BDFWYFhXj9Ql4FeMdQoRhRF6CE1o3pMrdM_C4jNFL2ybrHfQGXgZdwNYpeOljKr54d1CutGt7uBqd3F8fbLqF361KOgzwLCY7tEkreN77QYexbwNc2T6FY2_WoHVwbbfW3cBvVjm9gxntQ_wEl5mdgo8bndFbDX-mUe1egxem7aN-c6xz8Gt1dn36tVj_OL84Xa4LSVmTihpVVCFDCKGGG1oRraquMaWsaKUYIg3ikjQdV53ucFUzWktsGsYUZcp0vKRz8OHAdcGIe2mFb-2-3nhxH8Ty6vpCYIQJnc4cfD6YN2M3aCW1yxv2YhPy9mG3b_1fcfY2g7aCc4bLEmfA-yMg-N-jjkkMNkrd963TfoyCsAahmtN6shYHq8xfE4M2T2MwElPuIucuptzFlHv2v_v3bU_uv0HTP_Z5qz8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2780069361</pqid></control><display><type>article</type><title>Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study</title><source>PubMed Central</source><creator>Park, Jin Ha ; Kim, So Yeon ; Cho, Jin Sun ; Shin, Dongkwan ; Ham, Sung Yeon ; Kim, Hyesu ; Kwak, Young-Lan</creator><creatorcontrib>Park, Jin Ha ; Kim, So Yeon ; Cho, Jin Sun ; Shin, Dongkwan ; Ham, Sung Yeon ; Kim, Hyesu ; Kwak, Young-Lan</creatorcontrib><description><![CDATA[The estimated glomerular filtration rate (eGFR) at 6 months after donation (eGFR
) is strongly associated with the risk of end-stage renal disease in living kidney donors. This study aimed to investigate the incidence of eGFR
<60 mL/min/1.73 m² (eGFR
<60) and identify the risk factors that can predict the occurrence of eGFR
<60 in living kidney donors.
Living kidney donors who underwent nephrectomy at Severance Hospital between January 2009 and December 2019 were identified. We excluded 94 of 1233 donors whose creatinine values at 6 months after donation were missing. The risk factors for eGFR
<60 were assessed using multivariate regression analysis. The optimal cutoff points for candidate risk factors for predicting eGFR
<60 occurrence were determined using the Youden index.
The eGFR
<60 occurred in 17.3% of the participants. Older age (≥44 years), history of hypertension, lower preoperative eGFR (<101 mL/min/1.73 m²), and degree of increase in creatinine levels on postoperative day 2 compared to those before surgery (ΔCr2_pre) (≥0.39 mg/dL) increased the risk of eGFR
<60. The addition of ΔCr2_pre to preoperative eGFR yielded a higher predictive accuracy for predicting eGFR
<60 than that with preoperative eGFR alone {area under the receiver operating characteristic curve=0.886 [95% confidence interval (CI), 0.863-0.908] vs. 0.862 (95% CI, 0.838-0.887),
<0.001}.
The incidence of eGFR
<60 was 17.3%. Older age, lower preoperative eGFR, history of hypertension, and greater ΔCr2_pre were associated with the occurrence of eGFR
<60 after living donor nephrectomy. The combination of preoperative eGFR and ΔCr2_pre showed the highest predictive power for eGFR
<60.]]></description><identifier>ISSN: 0513-5796</identifier><identifier>EISSN: 1976-2437</identifier><identifier>DOI: 10.3349/ymj.2022.0541</identifier><identifier>PMID: 36825349</identifier><language>eng</language><publisher>Korea (South): Yonsei University College of Medicine</publisher><subject>Creatinine ; Glomerular Filtration Rate ; Humans ; Hypertension ; Kidney - physiology ; Kidney - surgery ; Kidney Transplantation - adverse effects ; Living Donors ; Nephrectomy - adverse effects ; Original ; Retrospective Studies ; 의학일반</subject><ispartof>Yonsei Medical Journal, 2023, 64(3), , pp.221-227</ispartof><rights>Copyright: Yonsei University College of Medicine 2023.</rights><rights>Copyright: Yonsei University College of Medicine 2023 2023 Yonsei University College of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c378t-6053d0f2223f9f352ed5b8f4c535d702809c28b9dbeb156736c1f877d37dfb943</cites><orcidid>0000-0002-4459-8214 ; 0000-0002-8534-9337 ; 0000-0001-8619-4595 ; 0000-0002-2984-9927 ; 0000-0002-1398-3304 ; 0000-0001-5352-157X ; 0000-0002-5408-4188</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971441/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971441/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27906,27907,53773,53775</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36825349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002931793$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Jin Ha</creatorcontrib><creatorcontrib>Kim, So Yeon</creatorcontrib><creatorcontrib>Cho, Jin Sun</creatorcontrib><creatorcontrib>Shin, Dongkwan</creatorcontrib><creatorcontrib>Ham, Sung Yeon</creatorcontrib><creatorcontrib>Kim, Hyesu</creatorcontrib><creatorcontrib>Kwak, Young-Lan</creatorcontrib><title>Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study</title><title>Yonsei medical journal</title><addtitle>Yonsei Med J</addtitle><description><![CDATA[The estimated glomerular filtration rate (eGFR) at 6 months after donation (eGFR
) is strongly associated with the risk of end-stage renal disease in living kidney donors. This study aimed to investigate the incidence of eGFR
<60 mL/min/1.73 m² (eGFR
<60) and identify the risk factors that can predict the occurrence of eGFR
<60 in living kidney donors.
Living kidney donors who underwent nephrectomy at Severance Hospital between January 2009 and December 2019 were identified. We excluded 94 of 1233 donors whose creatinine values at 6 months after donation were missing. The risk factors for eGFR
<60 were assessed using multivariate regression analysis. The optimal cutoff points for candidate risk factors for predicting eGFR
<60 occurrence were determined using the Youden index.
The eGFR
<60 occurred in 17.3% of the participants. Older age (≥44 years), history of hypertension, lower preoperative eGFR (<101 mL/min/1.73 m²), and degree of increase in creatinine levels on postoperative day 2 compared to those before surgery (ΔCr2_pre) (≥0.39 mg/dL) increased the risk of eGFR
<60. The addition of ΔCr2_pre to preoperative eGFR yielded a higher predictive accuracy for predicting eGFR
<60 than that with preoperative eGFR alone {area under the receiver operating characteristic curve=0.886 [95% confidence interval (CI), 0.863-0.908] vs. 0.862 (95% CI, 0.838-0.887),
<0.001}.
The incidence of eGFR
<60 was 17.3%. Older age, lower preoperative eGFR, history of hypertension, and greater ΔCr2_pre were associated with the occurrence of eGFR
<60 after living donor nephrectomy. The combination of preoperative eGFR and ΔCr2_pre showed the highest predictive power for eGFR
<60.]]></description><subject>Creatinine</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidney - physiology</subject><subject>Kidney - surgery</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Living Donors</subject><subject>Nephrectomy - adverse effects</subject><subject>Original</subject><subject>Retrospective Studies</subject><subject>의학일반</subject><issn>0513-5796</issn><issn>1976-2437</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpVkUtvEzEUhS0EoiGwZIu8REgT_JgZj1kgRaUpFUFUpaytGT9atzN2sD2p8kP6f_EkoYKFdWWdc7_r6wPAW4wWlJb84264WxBEyAJVJX4GZpizuiAlZc_BDFWYFhXj9Ql4FeMdQoRhRF6CE1o3pMrdM_C4jNFL2ybrHfQGXgZdwNYpeOljKr54d1CutGt7uBqd3F8fbLqF361KOgzwLCY7tEkreN77QYexbwNc2T6FY2_WoHVwbbfW3cBvVjm9gxntQ_wEl5mdgo8bndFbDX-mUe1egxem7aN-c6xz8Gt1dn36tVj_OL84Xa4LSVmTihpVVCFDCKGGG1oRraquMaWsaKUYIg3ikjQdV53ucFUzWktsGsYUZcp0vKRz8OHAdcGIe2mFb-2-3nhxH8Ty6vpCYIQJnc4cfD6YN2M3aCW1yxv2YhPy9mG3b_1fcfY2g7aCc4bLEmfA-yMg-N-jjkkMNkrd963TfoyCsAahmtN6shYHq8xfE4M2T2MwElPuIucuptzFlHv2v_v3bU_uv0HTP_Z5qz8</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Park, Jin Ha</creator><creator>Kim, So Yeon</creator><creator>Cho, Jin Sun</creator><creator>Shin, Dongkwan</creator><creator>Ham, Sung Yeon</creator><creator>Kim, Hyesu</creator><creator>Kwak, Young-Lan</creator><general>Yonsei University College of Medicine</general><general>연세대학교의과대학</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0002-4459-8214</orcidid><orcidid>https://orcid.org/0000-0002-8534-9337</orcidid><orcidid>https://orcid.org/0000-0001-8619-4595</orcidid><orcidid>https://orcid.org/0000-0002-2984-9927</orcidid><orcidid>https://orcid.org/0000-0002-1398-3304</orcidid><orcidid>https://orcid.org/0000-0001-5352-157X</orcidid><orcidid>https://orcid.org/0000-0002-5408-4188</orcidid></search><sort><creationdate>20230301</creationdate><title>Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study</title><author>Park, Jin Ha ; Kim, So Yeon ; Cho, Jin Sun ; Shin, Dongkwan ; Ham, Sung Yeon ; Kim, Hyesu ; Kwak, Young-Lan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-6053d0f2223f9f352ed5b8f4c535d702809c28b9dbeb156736c1f877d37dfb943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Creatinine</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Kidney - physiology</topic><topic>Kidney - surgery</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Living Donors</topic><topic>Nephrectomy - adverse effects</topic><topic>Original</topic><topic>Retrospective Studies</topic><topic>의학일반</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Jin Ha</creatorcontrib><creatorcontrib>Kim, So Yeon</creatorcontrib><creatorcontrib>Cho, Jin Sun</creatorcontrib><creatorcontrib>Shin, Dongkwan</creatorcontrib><creatorcontrib>Ham, Sung Yeon</creatorcontrib><creatorcontrib>Kim, Hyesu</creatorcontrib><creatorcontrib>Kwak, Young-Lan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Yonsei medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Jin Ha</au><au>Kim, So Yeon</au><au>Cho, Jin Sun</au><au>Shin, Dongkwan</au><au>Ham, Sung Yeon</au><au>Kim, Hyesu</au><au>Kwak, Young-Lan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study</atitle><jtitle>Yonsei medical journal</jtitle><addtitle>Yonsei Med J</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>64</volume><issue>3</issue><spage>221</spage><epage>227</epage><pages>221-227</pages><issn>0513-5796</issn><eissn>1976-2437</eissn><abstract><![CDATA[The estimated glomerular filtration rate (eGFR) at 6 months after donation (eGFR
) is strongly associated with the risk of end-stage renal disease in living kidney donors. This study aimed to investigate the incidence of eGFR
<60 mL/min/1.73 m² (eGFR
<60) and identify the risk factors that can predict the occurrence of eGFR
<60 in living kidney donors.
Living kidney donors who underwent nephrectomy at Severance Hospital between January 2009 and December 2019 were identified. We excluded 94 of 1233 donors whose creatinine values at 6 months after donation were missing. The risk factors for eGFR
<60 were assessed using multivariate regression analysis. The optimal cutoff points for candidate risk factors for predicting eGFR
<60 occurrence were determined using the Youden index.
The eGFR
<60 occurred in 17.3% of the participants. Older age (≥44 years), history of hypertension, lower preoperative eGFR (<101 mL/min/1.73 m²), and degree of increase in creatinine levels on postoperative day 2 compared to those before surgery (ΔCr2_pre) (≥0.39 mg/dL) increased the risk of eGFR
<60. The addition of ΔCr2_pre to preoperative eGFR yielded a higher predictive accuracy for predicting eGFR
<60 than that with preoperative eGFR alone {area under the receiver operating characteristic curve=0.886 [95% confidence interval (CI), 0.863-0.908] vs. 0.862 (95% CI, 0.838-0.887),
<0.001}.
The incidence of eGFR
<60 was 17.3%. Older age, lower preoperative eGFR, history of hypertension, and greater ΔCr2_pre were associated with the occurrence of eGFR
<60 after living donor nephrectomy. The combination of preoperative eGFR and ΔCr2_pre showed the highest predictive power for eGFR
<60.]]></abstract><cop>Korea (South)</cop><pub>Yonsei University College of Medicine</pub><pmid>36825349</pmid><doi>10.3349/ymj.2022.0541</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4459-8214</orcidid><orcidid>https://orcid.org/0000-0002-8534-9337</orcidid><orcidid>https://orcid.org/0000-0001-8619-4595</orcidid><orcidid>https://orcid.org/0000-0002-2984-9927</orcidid><orcidid>https://orcid.org/0000-0002-1398-3304</orcidid><orcidid>https://orcid.org/0000-0001-5352-157X</orcidid><orcidid>https://orcid.org/0000-0002-5408-4188</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0513-5796 |
| ispartof | Yonsei Medical Journal, 2023, 64(3), , pp.221-227 |
| issn | 0513-5796 1976-2437 |
| language | eng |
| recordid | cdi_nrf_kci_oai_kci_go_kr_ARTI_10123012 |
| source | PubMed Central |
| subjects | Creatinine Glomerular Filtration Rate Humans Hypertension Kidney - physiology Kidney - surgery Kidney Transplantation - adverse effects Living Donors Nephrectomy - adverse effects Original Retrospective Studies 의학일반 |
| title | Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T07%3A50%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20Pre-%20and%20Post-Donation%20Renal%20Function%20with%20Midterm%20Estimated%20Glomerular%20Filtration%20Rate%20in%20Living%20Kidney%20Donors:%20A%20Retrospective%20Study&rft.jtitle=Yonsei%20medical%20journal&rft.au=Park,%20Jin%20Ha&rft.date=2023-03-01&rft.volume=64&rft.issue=3&rft.spage=221&rft.epage=227&rft.pages=221-227&rft.issn=0513-5796&rft.eissn=1976-2437&rft_id=info:doi/10.3349/ymj.2022.0541&rft_dat=%3Cproquest_nrf_k%3E2780069361%3C/proquest_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c378t-6053d0f2223f9f352ed5b8f4c535d702809c28b9dbeb156736c1f877d37dfb943%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2780069361&rft_id=info:pmid/36825349&rfr_iscdi=true |