Fatty Acid Composition of Adipose Tissues in Obese Mice and SD Rats Fed with Isaria sinclairii Powder

Isaria sinclairii (Cicada Dongchunghacho) was studied as a potential crude natural food in powdered form. The role of tissue fatty acids in relation to the anti-obesity effects of I. sinclairii (IS) was examined by feeding the powder to SD rats ad libitum at 0, 1.25, 2.5, 5 and 10% (calculated about...

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Published in:Toxicological research (Seoul) 2010, 26(3), , pp.185-192
Main Authors: Ahn, M.Y., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Seo, Y.J., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Ji, S.D., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Han, J.W., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Hwang, J.S., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Yun, E.Y., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea
Format: Article
Language:English
Subjects:
6 months treatment
ACIDE GRAS
ACIDOS GRASOS
Anti-diabetic effect
Biomedicine
FATTY ACIDS
Isaria sinclairii
Obese mice
Pharmacology/Toxicology
예방의학
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Summary:Isaria sinclairii (Cicada Dongchunghacho) was studied as a potential crude natural food in powdered form. The role of tissue fatty acids in relation to the anti-obesity effects of I. sinclairii (IS) was examined by feeding the powder to SD rats ad libitum at 0, 1.25, 2.5, 5 and 10% (calculated about 8 g/kg) of the feed for a period of 3 months and 6 months. The fatty acid composition profile as indicated GC-MS, showed significantly slight dose-dependent increases in the levels of unsaturated fatty acids, particularly, arachidonic acid (C20: 4n6), oleic acid, linoleic acid, eicosadienoic acid, eicosapentaenoic acid (EPA) (C20: 5) concentration in the the ad libitum IS-fed groups compared to the control group in SD abdominal fat over 6 month period. Over viewing of the SD and Ob mice treated Isaria sinclairii powder; there were increases in the single (mono) unsaturated fatty acids ratio but decreases in polyunsaturated fatty acid. In IS-fed groups in proportion to the treatment period, this Dongchunghacho also induced an increase in the level of same result of unsaturated fatty acid in C57BL/6 obese (ob/ob) mice over a 6-month period treatment compared to those given 10% dry mulberry leaf powder (ML) or silkworm powder mixed with the standard diet.
ISSN:1976-8257
2234-2753
DOI:10.5487/TR.2010.26.3.185