Systematic Assessment of the Positive Role of Arabidopsis thaliana GROWTH-REGULATING FACTORs in Regulation of Cell Proliferation During Leaf Growth

Leaf growth and development are primarily driven by cell proliferation and expansion. Among a number of genes involved in the regulation of cell proliferation, the GROWTH-REGULATING FACTOR (GRF) transcription factors have been established to act as positive regulators of cell proliferation and leaf...

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Bibliographic Details
Published in:Journal of plant biology = Singmul Hakhoe chi 2022, 65(5), , pp.413-422
Main Authors: Lee, Gah-Hee, Lee, Byung Ha, Jung, Jae-Hak, Lee, Sang-Joo, Mai, Tran-Thi, Kim, Jeong Hoe
Format: Article
Language:English
Subjects:
Angiosperms
Arabidopsis thaliana
Biomedical and Life Sciences
Carbohydrates
Cell cycle
Cell division
Cell growth
Cell proliferation
Distribution patterns
Gene regulation
Growth patterns
Kinases
Leaves
Life Sciences
Mutants
Mutation
Plant Breeding/Biotechnology
Plant Ecology
Plant Genetics and Genomics
Plant Sciences
Plant Systematics/Taxonomy/Biogeography
Research Article
Spatial distribution
Temporal distribution
Transcription factors
생물학
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Summary:Leaf growth and development are primarily driven by cell proliferation and expansion. Among a number of genes involved in the regulation of cell proliferation, the GROWTH-REGULATING FACTOR (GRF) transcription factors have been established to act as positive regulators of cell proliferation and leaf growth in angiosperms. While the Arabidopsis thaliana GRF family comprises nine members, not all members of the family have been experimentally confirmed for the positive role, not only due to no or only slight changes in leaf size of corresponding single mutants, but also due to unavailability of multiple mutants to overcome the obstacle. Furthermore, some discrepancies and confusion in their roles have been disclosed in the literature. Here, we systemically prepared a series of such multiple mutants and confirmed that all GRF members, except for GRF8, acted as positive regulators of cell proliferation and leaf growth. We also systematically examined the spatio-temporal distribution patterns of all nine GRF proteins in the leaf organ, and found that their distribution patterns were highly reminiscent of the behavior of the cell cycle arrest front. We therefore propose that GRFs play an important role in shaping the arrest front and growth patterns of leaves.
ISSN:1226-9239
1867-0725
DOI:10.1007/s12374-022-09366-1