Sarcopenia in chronic kidney disease: from bench to bedside

Sarcopenia is a condition characterized by a loss of muscle mass and function. In chronic kidney disease (CKD), where a chronic catabolic state exists, sarcopenia commonly occurs through various mechanisms, resulting in muscle wasting and decreased muscle endurance. Sarcopenic patients with CKD have...

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Bibliographic Details
Published in:The Korean journal of internal medicine 2023, 38(3), , pp.303-321
Main Authors: Kim, Da Woon, Song, Sang Heon
Format: Article
Language:English
Subjects:
Aged
chronic kidney disease
drugs
Humans
Inflammation
molecular mechanisms
Muscle, Skeletal - pathology
Oxidative Stress
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - diagnosis
Review
sarcopenia
Sarcopenia - etiology
내과학
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Summary:Sarcopenia is a condition characterized by a loss of muscle mass and function. In chronic kidney disease (CKD), where a chronic catabolic state exists, sarcopenia commonly occurs through various mechanisms, resulting in muscle wasting and decreased muscle endurance. Sarcopenic patients with CKD have high morbidity and mortality rates. Indeed, the prevention and treatment of sarcopenia are mandatory. An imbalance between protein synthesis and degradation in muscle and increased oxidative stress and inflammation persist in CKD and induce muscle wasting. In addition, uremic toxins negatively affect muscle maintenance. A variety of potential therapeutic drugs targeting these muscle-wasting mechanisms in CKD have been investigated, but most of the trials focused on aged patients without CKD, and none of these drugs have been approved for the treatment of sarcopenia so far. Further studies on the molecular mechanisms of sarcopenia in CKD and targets for potential therapeutics are needed to improve the outcomes of sarcopenic patients with CKD.
ISSN:1226-3303
2005-6648
DOI:10.3904/kjim.2022.338