Clinical significance of drug cessation on medication-related osteonecrosis of the jaw in patients with osteoporosis

• Published in: Journal of the Korean Association of Oral and Maxillofacial Surgeons 2023, 49(2), , pp.75-85
• Main Authors: Mustakim, Kezia Rachellea, Eo, Mi Young, Lee, Ju Young, Seo, Mi Hyun, Kim, Soung Min
• Format: Article
• Language: English
• Subjects: Original; 치의학
• ISSN: 2234-7550; 2234-5930
• DOI: 10.5125/jkaoms.2023.49.2.75

Suspending bisphosphonates (BPs) to reduce the risk and severity of medication-related osteonecrosis of the jaw (MRONJ) remains controversial. In this study, we quantitatively evaluated the clinical significance of BP suspension before surgery in osteoporosis patients with MRONJ. We analyzed 24 osteoporosis patients with MRONJ who were treated from 2012 to 2020 at Seoul National University Dental Hospital and compared the treatment outcomes of those who suspended BPs with those who did not. The number of surgical interventions, follow-up panoramic radiographs for relative bone density measurement, and laboratory blood tests including white blood cells, erythrocyte sedimentation rate, absolute neutrophil count, hemoglobin, hematocrit, and alkaline phosphatase were analyzed. ANOVA, Student's t -test, and Mann-Whitney U tests were used to compare results. Fisher's exact test was used to discover the association between treatment outcome and BP suspension, and Pearson's correlation test was used to measure the statistical relationship between the changes in serum inflammatory markers. The number of interventions was significantly higher in the non-drug suspension group due to recurrence (