Surface enhanced Raman scattering based molecule detection using self-assembled DNA nanostructures

A novel method of Surface Enhanced Raman Scattering (SERS) based molecular detection was developed using self-assembled DNA nanostructures. Molecule detection using rigid, shape-controllable DNA nanostructures provides significant advantages such as accurate control of the particle distance and geom...

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Bibliographic Details
Published in:Current applied physics 2015, 15(9), , pp.1032-1035
Main Authors: Kim, Myoungsoon, Lee, Junwye, Dugasani, Sreekantha Reddy, Huh, Nam, Park, Sung Ha, Park, Sang Chul
Format: Article
Language:English
Subjects:
Cy3
DNA nanotechnology
Gold nanoparticle
Self-assembly
Surface enhanced Raman scattering
물리학
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Summary:A novel method of Surface Enhanced Raman Scattering (SERS) based molecular detection was developed using self-assembled DNA nanostructures. Molecule detection using rigid, shape-controllable DNA nanostructures provides significant advantages such as accurate control of the particle distance and geometrical programmability of the DNA nanostructure. We successfully detected the Cy3 dye, a Raman-active molecule, at 1461, 1590, and 1619 cm−1 using a Ag-enhanced Au-DNA nanostructure. Consequently, DNA-guided SERS detection is expected to contribute significantly to molecular detecting systems in the near future. •A novel method of surface enhanced Raman scattering based molecular detection was developed using DNA nanostructures.•We detected the Cy3 at 1461, 1590, and 1619 cm−1 using a silver enhanced gold conjugated DNA nanostructure.•Molecule detection using DNA nanostructures provides accurate control of the particle distances.•DNA-guided SERS detection is expected to contribute significantly to molecular detecting systems in the near future.
ISSN:1567-1739
1878-1675
DOI:10.1016/j.cap.2015.06.003